Oligomerization process of Bcl-2 associated X protein revealed from intermediate structures in solution.
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Summary
The results not only reveal the on-pathway intermediates, but also suggest a ditopic oligomerization mechanism that may bridge the observed intermediate structures in solution to the large BAX assemblies lately observed on mitochondria.
- Type
- article
- Published
- 2017-03-15
- Cited by
- 8
- References
- 51
- OpenAlex
- https://openalex.org/W2593931212
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3407321
Keywords
Process (computing), Chemistry, Crystallography, Biophysics, Computer science
References
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- Determination of the regularization parameter in indirect-transform methods using perceptual criteria
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- BAX-induced apoptosis can be initiated through a conformational selection mechanism.
- Accurate assessment of mass, models and resolution by small-angle scattering
- Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
- Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.
- Determination of domain structure of proteins from X-ray solution scattering.
- Apoptosis: embedded in membranes.
- Mechanism of Insulin Fibrillation
- Bax dimerizes via a symmetric BH3:groove interface during apoptosis
- Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization
- Structural characterization of proteins and complexes using small-angle X-ray solution scattering.
- BAX Activation is Initiated at a Novel Interaction Site
- The power of two: protein dimerization in biology.
- The accessible surface area and stability of oligomeric proteins
- Global rigid body modeling of macromolecular complexes against small-angle scattering data.
Cited by
- Improving immunogenicity of influenza virus H7N9 recombinant hemagglutinin for vaccine development.
- Doubly spin-labeled nanodiscs to improve structural determination of membrane proteins by ESR
- Overexpressed IGFBP5 promotes cell proliferation and inhibits apoptosis of nucleus pulposus derived from rats with disc degeneration through inactivating the ERK/MAPK axis
- Identifying Protein Conformational Dynamics Using Spin-label ESR.
- Distinctive Low-Resolution Structural Features of Dimers of Antibody Drug Conjugates and Parent Antibody determined by Small-Angle X-Ray Scattering.
- PEGylation-based strategy to identify pathways involved in the activation of apoptotic BAX protein.
- An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation
- The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death
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