High-resolution arrays reveal burden of copy number variations on Parkinson disease genes associated with increased disease risk in random cohorts
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Summary
It is hypothesize that CNVs may not be the initiating event in the pathogenesis of PD and remain latent until additional secondary hits are acquired and also propose novel genes that may fall under the PD pathway which contribute in pathogenesis.
- Type
- article
- Published
- 2016-07-11
- Cited by
- 5
- References
- 32
- OpenAlex
- https://openalex.org/W27399248
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39328911
Keywords
Primary (astronomy), Perspective (graphical), Focus (optics), Science education, Mathematics education
References
- Adult neurogenesis in Parkinson’s disease
- MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity.
- WebGestalt: an integrated system for exploring gene sets in various biological contexts
- Molecular pathophysiology of Parkinson's disease.
- Comparison of genotyping using pooled DNA samples (allelotyping) and individual genotyping using the affymetrix genome-wide human SNP array 6.0
- Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
- The genetics of Parkinson disease: implications for neurological care
- High-Resolution Survey in Familial Parkinson Disease Genes Reveals Multiple Independent Copy Number Variation Events in PARK2
- Genetic Evidence for High-Altitude Adaptation in Tibet
- Increased Rate of Sporadic and Recurrent Rare Genic Copy Number Variants in Parkinson’s Disease Among Ashkenazi Jews
- Chromosomal translocations among the healthy human population: implications in oncogenesis
- Tiny non-coding RNAs in Parkinson's disease: implications, expectations and hypes.
- Global Spectrum of Copy Number Variations Reveals Genome Organizational Plasticity and Proposes New Migration Routes
- Implications of gene copy-number variation in health and diseases
- Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities.
- What genetics tells us about the causes and mechanisms of Parkinson's disease.
- Human Copy Number Variation and Complex Genetic Disease
- Copy-number variations, noncoding sequences, and human phenotypes.
- Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease
- Copy number variation in Parkinson's disease
Cited by
- Copy Number Variation Disorders
- Characterising the role of Brassica napus genomic structural variation in disease resistance
- Phosphorylated Tau targeted Small-molecule PROTACs for the treatment of Alzheimer’s disease and Tauopathies
- Role of CNTNAP2 in autism manifestation outlines the regulation of signaling between neurons at the synapse
- Copy Number Variation among Resistance Genes Analogues in Brassica napus
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