Registered report: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
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Summary
This report describes the proposed replication plan of key experiments from ‘Wnt activity defines colon cancer stem cells and is regulated by the microenvironment’ by Vermeulen and colleagues, published in Nature Cell Biology in 2010, and the results of the replications will be published in eLife.
- Type
- article
- Published
- 2015-08-19
- Cited by
- 14
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W26287525
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19926191
Keywords
Geology
References
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- G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences
- Interactions between cancer stem cells and their niche govern metastatic colonization
- Cancer stem cells: never Wnt away from the niche
- The MET oncogene is a functional marker of a glioblastoma stem cell subtype.
- A role for Wnt signalling in self-renewal of haematopoietic stem cells
- Wnt/β-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells.
- Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
- ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays.
- MET signaling regulates glioblastoma stem cells.
- An open investigation of the reproducibility of cancer biology research
- Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
- R: A language and environment for statistical computing.
Cited by
- LIG4 mediates Wnt signalling-induced radioresistance
- Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy
- Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance
- Enrichment of Colorectal Cancer Stem Cells by Spheroidal Culture and Gene Expression Analysis of Selected ABC Transporters
- Non-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors
- AGR2 is a target of canonical Wnt/β-catenin signaling and is important for stemness maintenance in colorectal cancer stem cells.
- Challenges for assessing replicability in preclinical cancer biology
- From “Junk DNA” to Clinically Relevant Tools for Cancer Diagnosis, Staging, and Tailored Therapies: The Incredible Case of Non-Coding RNAs
- Intricate relationship between cancer stemness, metastasis, and drug resistance
- Advancements in cancer stem cell therapy: The effective integration of traditional Chinese medicine and nanotechnology.
- Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
- Hyperglycaemia-Induced Metabolic Stress Promotes EMT-Driven Therapeutic Resistance in Cancer: Evidence of a Deleterious Feed-Forward Cycle
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