AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation
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Summary
It is shown that AMP activated protein kinase (AMPK) activation‐induced anti‐proliferative effects are, in part, mediated by inhibiting MTDH expression in MDA‐MB‐231 and BT‐549 triple negative breast cancer (TNBC) cells.
- Type
- dissertation
- Published
- 2015-10-01
- Cited by
- 51
- References
- 53
- Access
- Open access
- OpenAlex
- https://openalex.org/W26236947
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20713050
Keywords
Grounded theory, Information and Communications Technology, Qualitative research, Mainstream, Pedagogy
References
- The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
- SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation.
- Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells
- Mechanism of activation of protein kinase B by insulin and IGF‐1.
- Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
- AEG-1/MTDH/LYRIC: Clinical Significance
- Statin‐induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms
- 5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
- Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1.
- Knockdown of astrocyte elevated gene-1 inhibits tumor growth and modifies microRNAs expression profiles in human colorectal cancer cells.
- Cancer Cell Survival Following DNA Damage-mediated Premature Senescence Is Regulated by Mammalian Target of Rapamycin (mTOR)-dependent Inhibition of Sirtuin 1*
- Establishment and characterization of MTDH knockdown by artificial MicroRNA interference - functions as a potential tumor suppressor in breast cancer.
- Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells.
- Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity
- Astrocyte elevated gene-1 induces protective autophagy
- Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells.
- Metadherin, a cell surface protein in breast tumors that mediates lung metastasis.
- Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis.
Cited by
- Baicalin, a Chinese Herbal Medicine, Inhibits the Proliferation and Migration of Human Non-Small Cell Lung Carcinoma (NSCLC) Cells, A549 and H1299, by Activating the SIRT1/AMPK Signaling Pathway
- AEG-1/MTDH/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases.
- Autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling
- Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics
- Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats
- AMP-activated protein kinase and energy balance in breast cancer.
- miR-96 inhibits EMT by targeting AEG-1 in glioblastoma cancer cells
- Metformin-induced anticancer activities: recent insights
- Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.
- The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis.
- Compound C inhibits nonsense-mediated RNA decay independently of AMPK
- MicroRNA-143 is Associated With Pathological Complete Response and Regulates Multiple Signaling Proteins in Breast Cancer
- Recent therapeutic trends and promising targets in triple negative breast cancer.
- AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer
- The persisting puzzle of racial disparity in triple negative breast cancer: looking through a new lens.
- Induction of AMPK activation by N,N’-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers
- A novel metadherinΔ7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFĸB-SIRT3 axis
- mPGES-1/PGE2 promotes the growth of T-ALL cells in vitro and in vivo by regulating the expression of MTDH via the EP3/cAMP/PKA/CREB pathway
- Biochemical mechanism and biological effects of the inhibition of silent information regulator 1 (SIRT1) by EX-527 (SEN0014196 or selisistat)
- Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions.
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