Discovery of a high affinity and selective pyridine analog as a potential positron emission tomography imaging agent for cannabinoid type 2 receptor.
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Summary
2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands investigated for their potency and binding properties toward human and rodent CB1 and CB2 and 16 is a promising radiotracer for imaging CB2 in rodents.
- Type
- article
- Published
- 2015-05-14
- Cited by
- 52
- References
- 32
- OpenAlex
- https://openalex.org/W25950914
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37261759
Keywords
Computer science
References
- Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7
- The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects
- The CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset
- Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging.
- Medicinal chemical properties of successful central nervous system drugs
- Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.
- An admonition when measuring the lipophilicity of radiotracers using counting techniques.
- Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical study.
- Synthesis, radiolabeling and evaluation of novel 4-oxo-quinoline derivatives as PET tracers for imaging cannabinoid type 2 receptor.
- Pharmacology of cannabinoid CB1 and CB2 receptors.
- Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
- Cannabinoid CB2 receptors in human brain inflammation
- NEW CLASS OF POTENT LIGANDS FOR THE HUMAN PERIPHERAL CANNABINOID RECEPTOR
- Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus
- Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2)
- Labelling and biological evaluation of [(11)C]methoxy-Sch225336: a radioligand for the cannabinoid-type 2 receptor.
- N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
- Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor.
- Blood-brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone.
- CB2 receptor‐mediated migration of immune cells: it can go either way
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- Translocator protein and new targets for neuroinflammation
- Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography.
- Cannabinoid receptor 2 (CB2) agonists and antagonists: a patent update
- The Structure–Function Relationships of Classical Cannabinoids: CB1/CB2 Modulation
- Discovery of a fluorinated 4‐oxo‐quinoline derivative as a potential positron emission tomography radiotracer for imaging cannabinoid receptor type 2
- Synthesis and Biological Evaluation of Thiophene-Based Cannabinoid Receptor Type 2 Radiotracers for PET Imaging
- DMAP-promoted in situ activation of bromoacetic acid as a 2-carbon synthon for facile synthesis of pyridines and fused pyridin-2-ones
- Development of a High-Affinity PET Radioligand for Imaging Cannabinoid Subtype 2 Receptor.
- Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders
- Positron emission tomography in amyotrophic lateral sclerosis: Towards targeting of molecular pathological hallmarks
- Cannabinoid receptor type 2 (CB2) as one of the candidate genes in human carotid plaque imaging: Evaluation of the novel radiotracer [11C]RS-016 targeting CB2 in atherosclerosis.
- Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations
- Development of Highly Affine and Selective Fluorinated Cannabinoid Type 2 Receptor Ligands.
- Is the Cannabinoid CB2 Receptor a Major Regulator of the Neuroinflammatory Axis of the Neurovascular Unit in Humans?
- Chemical Tools for Studying Lipid-Binding Class A G Protein–Coupled Receptors
- A Novel Selective Inverse Agonist of the CB2 Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies
- Radioligands for positron emission tomography imaging of cannabinoid type 2 receptor.
- PET Imaging of Microglial Activation—Beyond Targeting TSPO
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