Versican silencing improves the antitumor efficacy of endostatin by alleviating its induced inflammatory and immunosuppressive changes in the tumor microenvironment.
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Summary
Versican silencing in the tumor microenvironment offers a promising approach to reverse the tumor refractoriness to antiangiogenic therapies.
- Type
- article
- Published
- 2015-06-01
- Cited by
- 36
- References
- 32
- Access
- Open access
- OpenAlex
- https://openalex.org/W25872924
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:769728
Keywords
Geography
References
- Effect of Endostatin on Preventing Postoperative Progression of Distant Metastasis in a Murine Lung Cancer Model
- Inflammation meets cancer, with NF-κB as the matchmaker
- Low‐dose endostatin normalizes the structure and function of tumor vasculature and improves the delivery and anti‐tumor efficacy of cytotoxic drugs in a lung cancer xenograft murine model
- Endostar, a modified recombinant human endostatin, exhibits synergistic effects with dexamethasone on angiogenesis and hepatoma growth.
- Myeloid-derived-suppressor cells as regulators of the immune system
- Monocyte and macrophage heterogeneity
- Rotundarpene inhibits toll-like receptor 2 activation-induced production of inflammatory mediators in keratinocytes by suppressing the Akt and NF-κB pathways.
- Versican overexpression in human breast cancer lesions: Known and new isoforms for stromal tumor targeting
- Discrepancies Between Antiangiogenic and Antitumor Effects of Recombinant Human Endostatin
- Macrophages, innate immunity and cancer: balance, tolerance, and diversity.
- Altered macrophage differentiation and immune dysfunction in tumor development.
- Tumor-associated macrophages correlate with vascular space invasion and myometrial invasion in endometrial carcinoma.
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition.
- Ligation of TLR2 by versican: a link between inflammation and metastasis.
- Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells.
- Gene Therapy with the Angiogenesis Inhibitor Endostatin in an Orthotopic Lung Cancer Murine Model
- Tumor-associated macrophages: a molecular perspective.
- The origin and function of tumor-associated macrophages.
- Trophic macrophages in development and disease
Cited by
- Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.
- NOVEL DELIVERY APPROACHES FOR CANCER THERAPEUTICS
- Hypoxia and TGF-β1 lead to endostatin resistance by cooperatively increasing cancer stem cells in A549 transplantation tumors
- The protective effects of bone marrow-derived mesenchymal stem cell (BMSC) on LPS-induced acute lung injury via TLR3-mediated IFNs, MAPK and NF-κB signaling pathways.
- Matricryptins Network with Matricellular Receptors at the Surface of Endothelial and Tumor Cells
- Targeting the Tumor Environment in Squamous Cell Carcinoma of the Head and Neck
- The accumulation of macrophages attenuates the effect of recombinant human endostatin on lung cancer
- Interplay of Extracellular Matrix and Leukocytes in Lung Inflammation
- Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis
- PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis
- Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs.
- Genetic variants in the exon region of versican predict survival of patients with resected early-stage hepatitis B virus-associated hepatocellular carcinoma
- Clinical significance of the TNF‐&agr; receptors, TNFRSF2 and TNFRSF9, on cell migration molecules Fascin‐1 and Versican in acute leukemia
- Proteoglycans as potential biomarkers in odontogenic tumors
- Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
- Context-dependent bioactivity of versican fragments.
- Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity
- Green Tea Polyphenol EGCG Attenuates MDSCs-mediated Immunosuppression through Canonical and Non-Canonical Pathways in a 4T1 Murine Breast Cancer Model
- Effect of endostatin on Wnt pathway of stem-like cells in bladder cancer in tumor microenvironment
- Versican: A Dynamic Regulator of the Extracellular Matrix
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