Ghrelin Therapy Improves Survival after Whole-Body Ionizing Irradiation or Combined with Burn or Wound: Amelioration of Leukocytopenia, Thrombocytopenia, Splenomegaly, and Bone Marrow Injury
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Summary
These novel results are the first to suggest that ghrelin therapy effectively improved survival by mitigating CI-induced leukocytopenia, thrombocytopania, and bone-marrow injury or the RI-induced decreased hemoglobin and hematocrit.
- Type
- article
- Published
- 2014-10-13
- Cited by
- 46
- References
- 49
- Access
- Open access
- OpenAlex
- https://openalex.org/W25374650
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13209688
Keywords
The Internet, Computer science, World Wide Web
References
- Ghrelin is a growth-hormone-releasing acylated peptide from stomach
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- Ghrelin as a Novel Therapy for Radiation Combined Injury
- Radiation Combined Injury: DNA Damage, Apoptosis, and Autophagy
- Modulation of Mortality by Tissue Trauma and Sepsis in Mice after Radiation Injury
- Ghrelin: Expression and Functions in the Central Nervous System
- Predicting multiple organ failure in patients with severe trauma.
- Skin Injuries Reduce Survival and Modulate Corticosterone, C-Reactive Protein, Complement Component 3, IgM, and Prostaglandin E2 after Whole-Body Reactor-Produced Mixed Field (n + γ-Photons) Irradiation
- The effects of ghrelin on inflammation and the immune system.
- Pegylated G-CSF Inhibits Blood Cell Depletion, Increases Platelets, Blocks Splenomegaly, and Improves Survival after Whole-Body Ionizing Irradiation but Not after Irradiation Combined with Burn
- Significance of beta-radiation skin burns in Chernobyl patients for the theory and practice of radiopathology.
- Progress in Research on Radiation Combined Injury in China
- Immunomodulatory actions of central ghrelin in diet-induced energy imbalance.
- Studies on Acute Total Body Irradiation in Animals: 1. EFFECT OF STREPTOMYCIN FOLLOWING EXPOSURE TO A THERMAL BURN AND IRRADIATION
- Participation of bone marrow derived cells in cutaneous wound healing
- Effects of the "special bomb": recollections of a neurosurgeon in Hiroshima, August 8-15, 1945.
- Effect of ghrelin on chronic liver injury and fibrogenesis in male rats: possible role of nitric oxide.
- The influence of external body radiation on mortality from thermal burns.
- Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture.
- Reduction of T cell-derived ghrelin enhances proinflammatory cytokine expression: implications for age-associated increases in inflammation.
Cited by
- Ghrelin therapy mitigates bone marrow injury and splenocytopenia by sustaining circulating G-CSF and KC increases after irradiation combined with wound
- Skin wound trauma, following high-dose radiation exposure, amplifies and prolongs skeletal tissue loss.
- Protracted Oxidative Alterations in the Mechanism of Hematopoietic Acute Radiation Syndrome
- 3‐aminobenzamide, a poly (ADP ribose) polymerase inhibitor, enhances wound healing in whole body gamma irradiated model
- Bone Marrow Mesenchymal Stem Cells Increase Survival after Ionizing Irradiation Combined with Wound Trauma: Characterization and Therapy
- Burns: Pathophysiology of Systemic Complications and Current Management
- Ghrelin accelerates wound healing through GHS-R1a-mediated MAPK-NF-κB/GR signaling pathways in combined radiation and burn injury in rats
- MDP: A Deinococcus Mn2+-Decapeptide Complex Protects Mice from Ionizing Radiation
- Development of a combined radiation and full thickness burn injury minipig model to study the effects of uncultured adipose-derived regenerative cell therapy in wound healing
- Thrombopoietin Receptor Agonist Mitigates Hematopoietic Radiation Syndrome and Improves Survival after Whole-Body Ionizing Irradiation Followed by Wound Trauma
- A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures
- Utilization of ICU Data to Improve 30 and 60 Day Mortality Models
- Ghrelin Therapy Decreases Incidents of Intracranial Hemorrhage in Mice after Whole-Body Ionizing Irradiation Combined with Burn Trauma
- Combined Therapy of Pegylated G-CSF and Alxn4100TPO Improves Survival and Mitigates Acute Radiation Syndrome after Whole-Body Ionizing Irradiation Alone and Followed by Wound Trauma
- Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury
- Ghrelin mediates exercise endurance and the feeding response post-exercise
- Polymorphism of regulatory region of GHRL gene (‐2531C>T) as a promising predictive factor for radiotherapy‐induced oral mucositis in patients with head neck cancer
- dTMP-GH Fusion Protein Therapy Improves Survival after Radiation Injury Combined with Skin-Burn Trauma in Mice
- Radiation: a poly-traumatic hit leading to multi-organ injury
- A novel therapy, using Ghrelin with pegylated G-CSF, inhibits brain hemorrhage from ionizing radiation or combined radiation injury
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