Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease
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Summary
Results support the activation of an ATM signaling and DNA damage response network during the progression of AD dementia, while the progressive decrease in the levels of TIGAR suggests loss of protection initiated by ATM-p53 signaling against intensifying oxidative stress in AD.
- Type
- dissertation
- Published
- 2013-07-05
- Cited by
- 46
- References
- 100
- Access
- Open access
- OpenAlex
- https://openalex.org/W23861893
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8762465
Keywords
Humanities, Art
References
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- Myelination, oligodendrocytes, and serious mental illness
- Oxidative Stress and Aberrant Cell Cycle in Alzheimer’s Disease Lymphocytes: Diagnostic Prospects
- Caspase-Dependent Degradation of MDMx/MDM4 Cell Cycle Regulatory Protein in Amyloid β-induced Neuronal Damage
- Genomic Copy Number Variation Affecting Genes Involved in the Cell Cycle Pathway: Implications for Somatic Mosaicism
- Connecting the Dots Between Tau Dysfunction and Neurodegeneration
- p53 and Mitochondrial Function in Neurons
- C12orf5 (chromosome 12 open reading frame 5)
- BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
- Proliferating Cell Nuclear Antigen Binds DNA Polymerase-β and Mediates 1-Methyl-4-Phenylpyridinium-Induced Neuronal Death
- The Effects of Two Polymorphisms on p21cip1 Function and Their Association with Alzheimer’s Disease in a Population of European Descent
- X chromosome aneuploidy in the Alzheimer’s disease brain
- Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease
- Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases
- Altered expression of mRNA profiles in blood of early-onset schizophrenia
- Association between Single-Nucleotide Polymorphisms of the hOGG1,NEIL1,APEX1, FEN1,LIG1, and LIG3 Genes and Alzheimer's Disease Risk
- Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?
- Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury
- The Role of Gene Editing in Neurodegenerative Diseases
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