A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury.
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Summary
The results only partially replicate the findings that treatment with ibuprofen improves motor function after SCI but fail to replicate findings regarding enhanced axon growth.
- Type
- article
- Published
- 2013-10-01
- Cited by
- 41
- References
- 18
- OpenAlex
- https://openalex.org/W23830951
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9748508
Keywords
Computer science
References
- Inactivation of intracellular Rho to stimulate axon growth and regeneration.
- Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS
- Concepts and Methods for the Study of Axonal Regeneration in the CNS
- Deficits in bladder function following spinal cord injury vary depending on the level of the injury
- Targeting Recovery: Priorities of the Spinal Cord-Injured Population
- Chondroitinase ABC promotes functional recovery after spinal cord injury
- Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice
- Nonsteroidal Anti-Inflammatory Drugs Promote Axon Regeneration via RhoA Inhibition
- Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors
- Mechanical and thermal allodynia in chronic central pain following spinal cord injury
- Application of Rho Antagonist to Neuronal Cell Bodies Promotes Neurite Growth in Compartmented Cultures and Regeneration of Retinal Ganglion Cell Axons in the Optic Nerve of Adult Rats
- Rho Signaling Pathway Targeted to Promote Spinal Cord Repair
- Regeneration beyond the glial scar
- Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
- A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats
- Quantitative assessment of tactile allodynia in the rat paw.
- Replication and reproducibility in spinal cord injury research.
Cited by
- Design of an Animal Model for Testing Alginate Tissue Repair Scaffolds in Spinal Cord Injury
- Bone marrow stromal cells transplantation combined with ultrashortwave therapy promotes functional recovery on spinal cord injury in rats
- Spinal Cord Regeneration
- Chronic ibuprofen administration reduces neuropathic pain but does not exert neuroprotection after spinal cord injury in adult rats.
- Response to the report, "A re-assessment of treatment with a tyrosine kinase inhibitor (imatinib) on tissue sparing and functional recovery after spinal cord injury" by Sharp et al.
- Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis.
- Facilitating transparency in spinal cord injury studies using data standards and ontologies
- Gene Delivery Strategies to Promote Spinal Cord Repair
- Bridging the lesion—engineering a permissive substrate for nerve regeneration
- Neuroinflammation: Friend or Foe, Its a Matter of Time?
- Recent Efforts to Optimize the Predictive Value of Preclinical Study
- Ketorolac Administration Attenuates Retinal Ganglion Cell Death After Axonal Injury.
- Bone marrow mesenchymal stem cells combined with minocycline improve spinal cord injury in a rat model.
- SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol
- Neurological Aspects of Spinal Cord Injury
- Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention.
- Ibuprofen-loaded fibrous patches—taming inhibition at the spinal cord injury site
- Motor deficits following dorsal corticospinal tract transection in rats: voluntary versus skilled locomotion readouts
- Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders
- Therapeutic effects of simultaneous Photobiomodulation therapy (PBMT) and Meloxicam administration on experimental acute spinal cord injury: Rat animal model.
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