Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury
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Summary
The data suggested that autophagy might be interrupted due to the failure of ER cytoprotective capacity upon high glucose induced unmitigated stress, and the defective autophile might accelerate the irreparable progression of diabetic nephropathy.
- Type
- article
- Published
- 2013-04-11
- Cited by
- 228
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W23593240
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6944039
Keywords
Computer science
References
- Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival*
- Signal integration in the endoplasmic reticulum unfolded protein response
- The intersecting roles of endoplasmic reticulum stress, ubiquitin- proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease.
- Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.
- ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
- Quality control in the endoplasmic reticulum.
- Autophagy fights disease through cellular self-digestion
- Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
- Eating the endoplasmic reticulum: quality control by autophagy.
- 3D tomography reveals connections between the phagophore and endoplasmic reticulum
- Autophagy in Health and Disease: A Double-Edged Sword
- Autophagy: from phenomenology to molecular understanding in less than a decade
- Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines.
- Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.
- Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium
- Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
- The Role of Autophagy in Mammalian Development
- Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.
- A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation
- Cellular and Molecular Mechanisms of Proteinuria in Diabetic Nephropathy
Cited by
- Involvement of Endoplasmic Reticulum Stress in Albuminuria Induced Inflammasome Activation in Renal Proximal Tubular Cells
- Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models
- Impact of high glucose and AGEs on cultured kidney-derived cells. Effects on cell viability, lysosomal enzymes and effectors of cell signaling pathways.
- Ferulic Acid Protects Hyperglycemia-Induced Kidney Damage by Regulating Oxidative Insult, Inflammation and Autophagy
- Sirtuin 1: A Target for Kidney Diseases
- High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy
- 5'-Monophosphate-activated protein kinase (AMPK) improves autophagic activity in diabetes and diabetic complications
- Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?
- Endoplasmic reticulum and its role in diabetic nephropathy.
- Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy*
- Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy
- Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat.
- Interventions against nutrient-sensing pathways represent an emerging new therapeutic approach for diabetic nephropathy
- Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress.
- Autophagy in glomerular health and disease.
- Diabetic Kidney Disease: Pathophysiology and Therapeutic Targets
- Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice
- Heme oxygenase-1 enhances autophagy in podocytes as a protective mechanism against high glucose-induced apoptosis.
- Mechanisms and biological functions of autophagy in diseased and ageing kidneys
- Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease
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