Respiratory chain complex II as general sensor for apoptosis.
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Summary
Future studies on these mitochondrial processes will help refine this model, unravel the contribution of mutations in complex II subunits as the cause of degenerative neurological diseases and tumorigenesis, and aid in discovering novel interference options.
- Type
- dissertation
- Published
- 2013-05-01
- Cited by
- 83
- References
- 109
- Access
- Open access
- OpenAlex
- https://openalex.org/W23000077
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:13623141
Keywords
Bearing (navigation), Vibration, Damper, Ball (mathematics), Lubrication
References
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- Mutations in SDHC cause autosomal dominant paraganglioma, type 3
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- The Contribution of Mitochondrial Respiratory Complexes to the Production of Reactive Oxygen Species
- Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria.
- The Quinone-Binding and Catalytic Site of Complex II
- Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas.
- The SDH mutation database: an online resource for succinate dehydrogenase sequence variants involved in pheochromocytoma, paraganglioma and mitochondrial complex II deficiency
- High-throughput isolation of ultra-pure plasmid DNA by a robotic system
- Succinate Dehydrogenase—Assembly, Regulation and Role in Human Disease
- Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency
- Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II
- SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma.
- The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway.
- The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction.
- The hallmarks of cancer
Cited by
- Investigation of the Assembly, Activity, and Lipid Dependence of Mitochondrial Respiratory Complex II via Model Membrane Systems
- Pheochromocytoma: Gasping for Air
- Mitochondrial-Mediated Apoptosis Pathway in Alveolar Epithelial Cells Exposed to the Metals in Combustion-Generated Particulate Matter
- Mitochondria : a target for anticancer therapy
- Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival
- Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation
- Effect of experimental complex III deficiency on respiratory chain assembly and function
- Gastrointestinal and hepatic manifestations of mitochondrial disorders
- The Paradox of Mitochondrial Dysfunction and Extended Longevity
- Mitochondrial substrates in cancer: drivers or passengers?
- Powerhouse down: Complex II dissociation in the respiratory chain.
- Electrophysiological and molecular mechanisms of protection by iron sucrose against phosphine-induced cardiotoxicity: a time course study
- The mitochondrial permeability transition pore and its adaptive responses in tumor cells
- ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use
- Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.
- Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells
- UV Differentially Induces Oxidative Stress, DNA Damage and Apoptosis in BCR-ABL1-Positive Cells Sensitive and Resistant to Imatinib
- Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain.
- Mitochondrially Targeted Nanoparticles Based on α-TOS for the Selective Cancer Treatment.
- Effects of p66shc expression on bioenergetics and cell viability of b-cell chronic lymphocytic leukemia
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