Properties and identification of antibiotic drug targets
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Summary
It is suggested that antibiotic discovery programs would be more likely to succeed if new targets are chosen from this set of target like proteins or their homologues, many of which have unknown function.
- Type
- article
- Published
- 2010-04-20
- Cited by
- 55
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W20406434
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17463079
Keywords
Computer science
References
- Biocomputational strategies for microbial drug target identification.
- Mechanisms of bacterial resistance to antimicrobial agents.
- A simple method for displaying the hydropathic character of a protein.
- Aminoglycoside 2′-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates
- DrugBank: a knowledgebase for drugs, drug actions and drug targets
- Global Functional Atlas of Escherichia coli Encompassing Previously Uncharacterized Proteins
- Structural Basis for the Recognition of Isoleucyl-Adenylate and an Antibiotic, Mupirocin, by Isoleucyl-tRNA Synthetase*
- Statistics of Local Complexity in Amino Acid Sequences and Sequence Databases
- Basic local alignment search tool.
- New targets and screening approaches in antimicrobial drug discovery.
- Why metabolic enzymes are essential or nonessential for growth of Escherichia coli K12 on glucose.
- Resistance to antibiotics mediated by target alterations.
- DNA gyrase as a drug target.
- Gene Ontology: tool for the unification of biology
- Mechanisms of antimicrobial resistance in bacteria.
- The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
- PSORTdb: a protein subcellular localization database for bacteria
- Properties and identification of human protein drug targets
- Prediction of human protein function according to Gene Ontology categories
- Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity
Cited by
- An insight into the exploration of druggable genome of Streptococcus gordonii for the identification of novel therapeutic candidates.
- Computational aspects of presence of drug resistance mechanisms
- Study of Environmental and Antimicrobial Agents Impact on Features of Bacterial Growth
- Drug discovery and the use of computational approaches for infectious diseases.
- In Silico Prediction of Drug Targets in Phytopathogenic Pseudomonas syringae pv. phaseolicola: Charting a Course for Agrigenomics Translation Research
- Preclinical evaluation and molecular docking of 2, 5-di-tert-butyl-1, 4-benzoquinone (DTBBQ) from Streptomyces sp. VITVSK1 as a potent antibacterial agent
- Antimicrobial nanotechnology: its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology.
- Retrieval of Enterobacteriaceae drug targets using singular value decomposition
- A network flow approach to predict drug targets from microarray data, disease genes and interactome network - case study on prostate cancer
- Probing molecular choreography through single-molecule biochemistry
- Hybrid imbalanced data classifier models for computational discovery of antibiotic drug targets
- Expression, purification and characterization of the Biotin transporter from Staphylococcus aureus.
- Genome-Wide Identification of Potential Drug Target in Enterobacteriaceae Family: A Homology-Based Method
- Prediction of mammalian essential genes based on sequence and functional features
- Identification and characterization of potential druggable targets among hypothetical proteins of extensively drug resistant Mycobacterium tuberculosis (XDR KZN 605) through subtractive genomics approach
- Potential and use of bacterial small RNAs to combat drug resistance: a systematic review
- An integrated computational hierarchy for identification of potent inhibitors against Shikimate Kinase enzyme from Shigella sonnei , a major cause of global dysentery
- Subtractive Genomics, Molecular Docking and Molecular Dynamics Simulation Revealed LpxC as a Potential Drug Target Against Multi-Drug Resistant Klebsiella pneumoniae
- A Systematic In Silico Analysis of the Legionellaceae Family for Identification of Novel Drug Target Candidates
- Chemical Space of Escherichia coli Dihydrofolate Reductase Inhibitors: New Approaches for Discovering Novel Drugs for Old Bugs
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