Forty Percent Methionine Restriction Decreases Mitochondrial Oxygen Radical Production and Leak at Complex I During Forward Electron Flow and Lowers Oxidative Damage to Proteins and Mitochondrial DNA in Rat Kidney and Brain Mitochondria
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Summary
It is concluded that methionine is the only dietary factor responsible for the decrease in mitochondrial ROS production and oxidative stress, and likely for part of the longevity extension effect, occurring in DR.
- Type
- article
- Published
- 2009-12-01
- Cited by
- 120
- References
- 77
- OpenAlex
- https://openalex.org/W20041736
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33629884
Keywords
Environmental planning, Environmental resource management, Environmental science, Environmental protection, Business
References
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Cited by
- Review: can diet influence the selective advantage of mitochondrial DNA haplotypes?
- The mitochondrial free radical theory of aging.
- The Influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction
- Efecto del hidroxitirosol sobre la cardiotoxicidad producida por doxorubicina
- Plant-based Diets and Low-Insulin Lifestyles May Suppress Oxidative Stress By Disinhibiting FOXO3a
- Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress
- An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms
- Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart
- Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype
- Biogerontology in Spain: the most significant studies
- Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification
- Methionine and homocysteine modulate the rate of ROS generation of isolated mitochondria in vitro
- Traumatic brain injury: oxidative stress and neuroprotection.
- Specific lipidome signatures in central nervous system from methionine-restricted mice.
- Dietary protein mediates a trade-off between larval survival and the development of male secondary sexual traits
- Membrane lipid unsaturation as physiological adaptation to animal longevity
- Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria
- Methionine restriction slows down senescence in human diploid fibroblasts
- Effect of Every Other Day Feeding on Mitochondrial Free Radical Production and Oxidative Stress in Mouse Liver
- Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents.
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