Rapamycin: the cure for all that ails.

Keywords

TOR signaling, Life span, Sirolimus, Biology, PI3K/AKT/mTOR pathway

References

• Why do we age?Thomas B. L. Kirkwood, Steven N. Austad — 2000
• Molecular mechanisms of mTOR-mediated translational controlXiaoju Max, John Blenis — 2009
• Overview of caloric restriction and ageing.Edward J. Masoro — 2005
• Stress and mTORture signalingJan H. Reiling, David M. Sabatini — 2006
• Targeting mammalian target of rapamycin (mTOR) for health and diseases.Chi Kwan Tsang, Haiyan Qi, Leroy F. Liu — 2007
• Rapamycin fed late in life extends lifespan in genetically heterogeneous miceDavid E. Harrison, Randy Strong, Z. Dave Sharp — 2009
• Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to NutrientsMatt Kaeberlein, Ryan Powers, Kristan K. Steffen — 2005
• The plasticity of aging: insights from long-lived mutants.Cynthia Kenyon — 2005
• Rapamycin's resurrection: a new way to target the cancer cell cycle.K. Garber — 2001

Cited by

• Chronic mechanistic target of rapamycin inhibition: preventing cancer to delay aging, or vice versa?.Z. Dave Sharp, Tyler J. Curiel, Carolina B. Livi — 2013
• The amelioration of metabolic disorders in early stage diabetic rats by resveratrol is associated with mTORC1 regulationJeng-Yuan Yao, Chun-Kai Liu, Kuan‐Hsing Chen — 2015
• p53 and rapamycin are additiveBarbara A. Christy, Marco Demaria, Judith Campisi — 2015
• Listening to public concerns about human life extensionBrad Partridge, Jayne Lucke, Wayne Hall — 2010
• Tissue-Specific Responses of IGF-1/Insulin and mTOR Signaling in Calorie Restricted RatsNaveen Sharma, Carlos M. Castorena, Gregory D. Cartee — 2012
• Rapamycin promotes β-amyloid production via ADAM-10 inhibitionShe‐Qing Zhang, Jon Salemi, Hauyan Hou — 2010
• Aging and TOR: interwoven in the fabric of lifeZ. Dave Sharp — 2011
• mTORC1 and p53Paul Hasty, Z. Dave Sharp, Tyler J. Curiel — 2013
• eRapa Restores A Normal Life Span in a FAP Mouse ModelPaul Hasty, Carolina B. Livi, Sherry G. Dodds — 2013
• Rapamycin increases RSV RNA levels and survival of RSV-infected dendritic cell depending on T cell contact.Deise Nascimento de Freitas, Rodrigo Benedetti Gassen, Tiago Fazolo — 2016
• LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axisXuedan Sun, Rick FrancisThorne, Xu Dong Zhang — 2019
• Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval DrosophilaSamuel Potter, Jacob Sifers, Emily Yocom — 2019
• LncRNA GUARDIN suppresses cellular senescence through a LRP130‐PGC1α‐FOXO4‐p21‐dependent signaling axisXuedan Sun, Rick F. Thorne, Xu Dong Zhang — 2020
• α‐ketoglutarate delays age‐related fertility decline in mammalsZhenzhen Zhang, Changjiu He, Yu Gao — 2021
• mTOR, Aging, and Cancer: A Dangerous LinkZ. D. Sharp, P. Hasty — 2016
• Roles of AMP, ADP, ATP, and AMPK in Healthy Energy Boosting and Prolonged Life SpanDurgavati Yadav, Y. Tripathi, Prabhakar Singh — 2017

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• Brain and LongevityCaleb E. Finch, Jean‐Marie Robine, Yves Christen — 2003
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• Influence of the Protein Level of the Diet on the Longevity of CockroachesMykola H. Haydak — 1953
• Rapamycin reduces Drosophila longevity under low nutritionEugenia Villa-Cuesta, Frances Fan, David M. Rand — 2014