Increasing organismal healthspan by enhancing mitochondrial protein quality control
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Summary
The reported genetic manipulation of Podospora anserina LON levels, an AAA+ family serine protease localized in the matrix fraction of mitochondria, proved to be a successful intervention in organismal ageing and it led to an increase in the healthy lifespan, the healthspan, of P. an Serina.
- Type
- article
- Published
- 2009-06-21
- Cited by
- 127
- References
- 38
- OpenAlex
- https://openalex.org/W19543272
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19422319
Keywords
Political science
References
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- A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina
- Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism
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- Oxidative Damage to Specific Proteins in Replicative and Chronological-aged Saccharomyces cerevisiae
- A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes
- Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina
Cited by
- The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control.
- Mitochondrial Quality Control: Impact on Aging and Life Span - A Mini-Review
- Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
- Mitochondrial protein quality control systems in aging and disease.
- RCF1-dependent respiratory supercomplexes are integral for lifespan-maintenance in a fungal ageing model
- New roles for mitochondrial proteases in health, ageing and disease
- Cyclophilin D links programmed cell death and organismal aging in Podospora anserina
- Mitochondrial dysfunction, proteotoxicity, and aging: causes or effects, and the possible impact of NAD+-controlled protein glycation.
- Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina
- Degradation of the E. coli small heat-shock proteins by the AAA+ protease lon : significance to protein quality-control
- The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease
- Roles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation, and chaperone activity
- Dietary- and fasting-based interventions as novel approaches to improve the efficacy of cancer treatment
- Mitochondrial quality control: a matter of life and death for neurons
- Mitochondrial Lon protease at the crossroads of oxidative stress, ageing and cancer
- Multitasking in the mitochondrion by the ATP-dependent Lon protease
- Mitophagy in yeast: Molecular mechanisms and physiological role.
- Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina
- Alternative Oxidase Dependent Respiration Leads to an Increased Mitochondrial Content in Two Long-Lived Mutants of the Ageing Model Podospora anserina
- Impaired quality control of mitochondria: aging from a new perspective.
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