Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis.
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Summary
The data indicate that genetic predisposition plays an important role in the pathogenesis of ACPA-negative RA, for which most individual genetic risk factors remain to be identified.
- Type
- article
- Published
- 2009-04-01
- Cited by
- 273
- References
- 41
- OpenAlex
- https://openalex.org/W2133480655
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19465862
Keywords
Heritability, Zygosity, Medicine, Allele, Immunology
References
- Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.
- Mathematical Statistics: Basic Ideas and Selected Topics
- Association of the PTPN22 C1858T single-nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort.
- Twin concordance rates for rheumatoid arthritis: results from a nationwide study.
- Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
- The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.
- An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility.
- A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
- The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis.
- Individual-specific ‘fingerprints’ of human DNA
- Measurement Error in Nonlinear Models: A Modern Perspective
- The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.
- Quantifying the exact role of HLA-DRB1 alleles in susceptibility to inflammatory polyarthritis: results from a large, population-based study.
- Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
- A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
- New Serum Factor in Patients with Rheumatoid Arthritis: The Antiperinuclear Factor *
- A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions.
- Revised criteria for the classification of rheumatoid arthritis.
- Anti-keratin antibodies in rheumatoid arthritis.
- The contribution of HLA to rheumatoid arthritis.
Cited by
- Clinical approaches to early inflammatory arthritis
- Genetics of rheumatoid arthritis: what have we learned?
- Lack of replication of interactions between polymorphisms in rheumatoid arthritis susceptibility: case–control study
- How undifferentiated arthritis evolves into chronic arthritis.
- Meta-analysis reveals PTPN22 1858C/T polymorphism confers susceptibility to rheumatoid arthritis in Caucasian but not in Asian population
- DNA Sequence Variants in Human Autoimmune Diseases
- Metabolomics of inflammatory arthritis
- The role of citrullination in the development of mouse and human inflammatory arthritis
- Expression of 9G4 idiotope on autoantibodies from patients with rheumatoid arthritis
- Self-tolerance in collagen induced arthritis
- The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register
- Personalized medicine in rheumatoid arthritis: Pharmacogenetics of anti-TNF and beyond.
- Lipid associated biomarkers in patients with systemic lupus erythematosus and rheumatoid arthritis
- Association between KIR gene polymorphisms and rheumatoid arthritis susceptibility: A meta-analysis.
- Immunogenetics of rheumatoid arthritis: Understanding functional implications.
- Marginal genetic effects estimation in family and twin studies using random‐effects models
- Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age.
- Twin studies of pain
- Apoptotic B cells: their interactions with macrophages and modulation by rituximab
- GENOME-WIDE ASSOCIATION STUDIES AT THE INTERFACE OF ALZHEIMER'S DISEASE AND EPIDEMIOLOGICALLY RELATED DISORDERS
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