The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications.
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Summary
Its target T-regulatory cells may be used for the clinical treatment of autoimmune diseases and future study could also focus on promotion of the beneficial effects of IFNgamma and blocking those unwanted IFNGamma-induced activities.
- Type
- article
- Published
- 2009-01-01
- Cited by
- 71
- References
- 95
- OpenAlex
- https://openalex.org/W18848698
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:30350622
Keywords
Poverty, Inner city, Economic growth, Geography, Urban poverty
References
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- IFN-γ-Producing γδ T Cells Help Control Murine West Nile Virus Infection 1
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- Enhanced osteoclast development in collagen-induced arthritis in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis
- Oral tolerance: mechanisms and therapeutic applications.
- Loss of IFN-γ Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen1
- Intranasal Vaccination with Proinsulin DNA Induces Regulatory CD4+ T Cells That Prevent Experimental Autoimmune Diabetes1
- Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ
- IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function.
- Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections.
- IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis.
- IFN Regulatory Factor-2 Cooperates with STAT1 to Regulate Transporter Associated with Antigen Processing-1 Promoter Activity1
- A randomized, double-blind study comparing twenty-four-week treatment with recombinant interferon-gamma versus placebo in the treatment of rheumatoid arthritis.
- CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis
- Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1-dependent Genes in Endothelial Cells
- CD8+ T-cells and their interaction with other cells in damage to islet beta-cells.
- A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
- Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens.
Cited by
- In vitro generation of human FOXP3+ regulatory T cells
- Interferon-gamma Mediated Host Responses to Enteric Pathogen, Citrobacter rodentium
- Combining chemotherapy with immunotherapy to treat mesothelioma : an investigation into the role of CD4+ T cells in a murine model
- Long Term Immunological Memory to Vaccinia Virus
- The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis
- The benzoxathiolone LYR‐71 down‐regulates interferon‐γ‐inducible pro‐inflammatory genes by uncoupling tyrosine phosphorylation of STAT‐1 in macrophages
- Antigen-Specific Blocking of CD4-Specific Immunological Synapse Formation Using BPI and Current Therapies for Autoimmune Diseases
- Combining anaerobic bacterial oncolysis with vaccination that blocks interleukin-10 signaling may achieve better outcomes for late stage cancer management
- T-bet regulates differentiation of forkhead box protein 3+ regulatory T cells in programmed cell death-1-deficient mice
- T-helper 17 lymphocytes in ocular cicatricial pemphigoid
- Genomic structure and characterization of mRNA expression pattern of porcine interferon gamma receptor 1 gene
- Aggregatibacter actinomycetemcomitans GroEL Protein Promotes Conversion of Human CD4+ T Cells into IFNγ IL10 Producing Tbet+ Th1 Cells
- Smoking Enhances the Proinflammatory Effects of Nucleotides on Cytokine Release from Human Lung
- Multiple sclerosis pharmacogenomics
- Enhancement of proteasome function by PA28α overexpression protects against oxidative stress
- Correlates of cognitive dysfunction in multiple sclerosis.
- Subpopulations of equine blood lymphocytes expressing regulatory T cell markers.
- Transcription factor Ets-1 in cytokine and chemokine gene regulation.
- Altered Phenotype of Blood Dendritic Cells in Patients with Acute Pneumonia
- Impact of cytokine in type 1 narcolepsy: Role of pandemic H1N1 vaccination ?
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