Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model
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Summary
Five previously unreported gene products are revealed that significantly protect against age- and dose-dependent α-syn-induced degeneration in the dopamine neurons of transgenic worms, and one gene reported to cause neurodegeneration in knockout mice.
- Type
- article
- Published
- 2008-01-15
- Cited by
- 303
- References
- 52
- Access
- Open access
- OpenAlex
- https://openalex.org/W18182484
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12605210
Keywords
Political science
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Cited by
- New animal models of Parkinson's disease
- alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology
- Modeling dopamine neuron degeneration in Caenorhabditis elegans.
- Necrotic cell death in Caenorhabditis elegans.
- Novel malaria parasite proteins involved in erythrocyte invasion
- Protein metabolism and lifespan in Caenorhabditis elegans.
- Alpha-linolenic acid suppresses dopaminergic neurodegeneration induced by 6-OHDA in C. elegans.
- In Vivo GFP Knockdown by Cationic Nanogel-siRNA Polyplexes
- Elucidating the role of post-translational modifications of alpha-synuclein using semisynthesis
- Pharmacological maintenance of protein homeostasis could postpone age-related disease
- Lysosomal Impairment in Parkinson’s Disease
- A New Role for Laminins as Modulators of Protein Toxicity in Caenorhabditis elegans
- Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model
- Cellular function and toxicity of the Parkinson’s disease-related genes α-synuclein and catp-6 in C. elegans
- Low-Dose Bafilomycin Attenuates Neuronal Cell Death Associated with Autophagy-Lysosome Pathway Dysfunction
- Establishing the C. elegans uterine seam cell (utse) as a novel model for studying cell behavior
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