Identification of Essential Interacting Elements in K-Ras/Calmodulin Binding and Its Role in K-Ras Localization*
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Summary
Using a K-Ras with impaired binding to calmodulin but with membrane localization, it is demonstrated in striatal neurones that interaction between K- Ras and cal modulin was not required for Golgi K- ras translocation induced by Ca2+ influx.
- Type
- article
- Published
- 2008-04-18
- Cited by
- 71
- References
- 50
- Access
- Open access
- OpenAlex
- https://openalex.org/W1999981814
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45085533
Keywords
Calmodulin, Internalization, Calmodulin-binding proteins, Biology, Biochemistry
References
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- Identification and Characterization of a Calmodulin-binding Domain in Ral-A, a Ras-related GTP-binding Protein Purified from Human Erythrocyte Membrane*
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- Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs.
Cited by
- Calcium around the Golgi apparatus: implications for intracellular membrane trafficking.
- The Influence of DX-52-1 and Phosphorylation on the Interactions of Galectin-3 with its Binding Partners
- H-ras resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes.
- Regulation of K-Ras4B Membrane Binding by Calmodulin.
- High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors.
- CONFORMATIONAL DYNAMICS OF K-RAS AND H-RAS PROTEINS: IS THERE FUNCTIONAL SPECIFICITY AT THE CATALYTIC DOMAIN?
- Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum.
- Annexins--modulators of EGF receptor signalling and trafficking.
- Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
- The hypervariable region of K-Ras4B is responsible for its specific interactions with Calmodulin
- Mechanisms of Membrane Binding of Small GTPase K-Ras4B Farnesylated Hypervariable Region*
- Both the C-Terminal Polylysine Region and the Farnesylation of K-RasB Are Important for Its Specific Interaction with Calmodulin
- Dragging ras back in the ring.
- Differential involvement of H- and K-Ras in Raf-1 activation determines the role of calmodulin in MAPK signaling.
- The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer.
- Characterization and Functional Analysis of the Calmodulin-Binding Domain of Rac1 GTPase
- Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration*
- K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function
- CaM interaction and Ser181 phosphorylation as new K-Ras signaling modulators
- Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.
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