Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis
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Summary
The results indicate that NO alone is unlikely to induce oligodendrocyte injury, whereas its more potent byproduct peroxynitrite is a potential mediator of injury to oligodendedrocytes in MS.
- Type
- article
- Published
- 2007-07-01
- Cited by
- 71
- References
- 46
- OpenAlex
- https://openalex.org/W17437305
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45884040
Keywords
Computer science
References
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Cited by
- ACTH protects mature oligodendroglia from excitotoxic and inflammation‐related damage in vitro
- Characterization of molecular alterations in normal appearing white matter of multiple sclerosis brain tissue and its animal model experimental autoimmune encephalomyelitis
- White matter injury: Ischemic and nonischemic
- Glial influences on BBB functions and molecular players in immune cell trafficking.
- Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination
- A Comparative Evaluation of the Response to Peroxynitrite by a Brain Endothelial Cell Line and Control of the Effects by Drug Targeting
- Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for Multiple Sclerosis
- The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders
- The acute and chronic phases of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE) are ameliorated by the peroxynitrite decomposition catalyst, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinatoiron (III) chloride, (FeTPPS).
- Natural Approaches to Multiple Sclerosis
- Molecular Changes in White Matter Adjacent to an Active Demyelinating Lesion in Early Multiple Sclerosis
- Association analysis of nitric oxide synthases: NOS1, NOS2A and NOS3 genes, with multiple sclerosis
- Neuroprotective Effects of the Complement Terminal Pathway During Demyelination: Implications for Oligodendrocyte Survival
- Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia.
- Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity.
- In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytes
- Neuroinflammation and demyelination from the point of nitrosative stress as a new target for neuroprotection
- Role of glial cells in innate immunity and their role in CNS demyelination.
- Lame Ducks or Fierce Creatures? - The Role of Oligodendrocytes in Multiple Sclerosis
- Multiple sclerosis: molecular mechanisms and therapeutic opportunities.
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