Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases

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Summary

It is proposed that the Last Universal Common Ancestor of all extant organisms contained at least three SPOUT members, ancestors of contemporary RNA MTases that carry out m1G, m3U, and 2'O-ribose methylation, respectively.

Type
article
Published
2007-03-05
Cited by
180
References
113
Access
Open access

Keywords

Humanities, Philosophy

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