Single-molecule studies of complex systems: the replisome.
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Summary
In this review, the DNA replication machinery will be used as an example to illustrate recent progress in the development of various single-molecule techniques and its contribution to the understanding of the orchestration of multiple enzymatic processes in large biomolecular systems.
- Type
- article
- Published
- 2007-01-23
- Cited by
- 21
- References
- 87
- OpenAlex
- https://openalex.org/W17245491
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:82539326
Keywords
Computer science, Physics
References
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- Single-molecule studies of the effect of template tension on T7 DNA polymerase activity
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- Recombination initiation: easy as A, B, C, D... chi?
- Single-molecule investigation of the T4 bacteriophage DNA polymerase holoenzyme: multiple pathways of holoenzyme formation.
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- Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase
- Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins.
- Interaction between the T4 helicase-loading protein (gp59) and the DNA polymerase (gp43): a locking mechanism to delay replication during replisome assembly.
- Transcription Against an Applied Force
- Transcription by single molecules of RNA polymerase observed by light microscopy
- Methods of single-molecule fluorescence spectroscopy and microscopy
Cited by
- Signals and noise in complex biological systems.
- Supported Lipid Bilayers and DNA Curtains for High-Throughput Single-Molecule Studies
- The structural dynamics of macromolecular processes
- Plant morphogenesis in vitro1
- The importance of surfaces in single-molecule bioscience.
- Single-Molecule Studies of DNA Replisome Function
- Single-cell manipulation on microfluidic chip by dielectrophoretic actuation and impedance detection
- DNA replication at the single-molecule level.
- Single molecule studies of homologous recombination
- Analysis of kinetic intermediates in single-particle dwell-time distributions.
- DNA based molecular motors.
- Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
- Characterizing the Final Steps of Chromosomal Replication at the Single-molecule Level in the Model System Escherichia coli
- Experimental and computational analysis of DNA unwinding and polymerization kinetics
- Modelling DNA replication fork stability and collapse using chromatin fiber analysis and the R-ODD-BLOBS program
- Applications of Computational Methods to Simulations of Proteins Dynamics
- Single-molecule characterization of microbial polysaccharides
- Assembly dynamics of supramolecular protein-DNA complexes studied by single-molecule fluorescence microscopy
- Single Molecule Studies of Nucleic Acid Enzymes
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