The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX‐2 Endowed with Anti‐Aggregatory and Vasodilating Activities
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Summary
New, selective COX‐2 furoxan derivatives endowed with anti‐aggregatory and vasodilating activities, and with potentially reduced cardiotoxicities are found, similar to the structurally related furazans.
- Type
- article
- Published
- 2005-07-01
- Cited by
- 33
- References
- 48
- OpenAlex
- https://openalex.org/W17193179
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32114323
Keywords
Nice, Psychological intervention, Audit, Overweight, Promotion (chess)
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Cited by
- Nitric oxide affects immune cells bioenergetics: long-term effects of nitric-oxide derivatives on leukaemic Jurkat cell metabolism.
- Étude métabolique des cellules myéloïdes suppressives dans le contexte du phénomène d'immunosuppression
- Optimisation du concept d'inhibition de Cyclooxygénase dans le traitement du cancer de la prostate
- Synthesis and biological evaluation of nitric oxide-donating analogues of sulindac for prostate cancer treatment.
- NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.
- An exploration of the mechanisms for the formation of 3,4-bis(4-aminofurazan-3-yl)-furoxan by density functional theory
- Mechanistic studies of copper(II)-mediated oxidation of vic-dioxime to furoxan
- Novel amino acids: synthesis of furoxan and sydnonimine containing amino acids and peptides as potential nitric oxide releasing motifs.
- Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth.
- Antiproliferative effects of COX-2 inhibitor celecoxib on human breast cancer cell lines
- Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents.
- Nitrooxymethyl‐Substituted Analogues of Rofecoxib: Synthesis and Pharmacological Characterization
- PLANEJAMENTO, SÍNTESE E AVALIAÇÃO FARMACOLÓGICA DE NOVOS COMPOSTOS 1,2,5-OXADIAZOL-2-N-ÓXIDO ÚTEIS COMO PREVENTIVOS DE ATEROTROMBOSE
- Design of hybrid heterocyclic systems with a furoxanylpyridine core via tandem hetero-Diels–Alder/retro-Diels–Alder reactions of (1,2,4-triazin-3-yl)furoxans
- Copper(II)-mediated oxidative transformation of vic-dioxime to furoxan: evidence for a copper(II)-dinitrosoalkene intermediate.
- A Series of COX‐2 Inhibitors Endowed with NO‐Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis
- Synthesis of Furoxans (1,2,5‐oxadiazole 2‐oxides) from Styrenes and Nitrosonium Tetrafluoroborate in Non‐Acidic Media and Mechanistic Study
- “Hole-catalyzed” cycloadditions of the gaseous ionized nitrile N -oxides Ph-C N + O and CH 3 C N + O with model dipolarophiles
- Synthesis of alkynyl furoxans. Rare carbon-carbon bond-forming reaction on a furoxan ring.
- Synthesis of cyanofuroxans from 4-nitrofuroxans via C-C bond forming reactions
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