The development of gene therapy: from monogenic recessive disorders to complex diseases such as cancer.
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Summary
This introductory chapter reviews the history of gene therapy since the early 1960s and presents in detail two major recurring themes in gene therapy: (1) the development of vector and delivery systems and (2) the design of strategies to fight or cure particular diseases.
- Type
- review
- Published
- 2009-01-01
- Cited by
- 45
- References
- 377
- OpenAlex
- https://openalex.org/W17148451
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27882885
Keywords
Genetic enhancement, Clinical trial, Cancer, Gene transfer, Vector (molecular biology)
References
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- Lentiviral vectors for treatment of haemophilia
- [Host defense peptides and peptidomimetics as new weapons for cancer treatment].
- Leptin gene therapy in the fight against diabetes
- Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer.
- Current status of gene therapy for cancer
- Recent developments in transposon-mediated gene therapy
- Targeting the oncogenic Met receptor by antibodies and gene therapy
- Gene therapy in Alzheimer’s disease – potential for disease modification
- Emerging uses for pediatric hematopoietic stem cells
- Sustained, localized transgene expression mediated from lentivirus-loaded biodegradable polyester elastomers
- Imaging Gene Expression in Live Cells and Tissues
- Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy
- Gene therapy for bone healing
- Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor
- Bacteriophage Mediates Efficient Gene Transfer in Combination with Conventional Transfection Reagents
- Vectors and strategies for nonviral cancer gene therapy
- The Clinical Progress of Gene Therapy and Its Ethical Standing
- The impact of gene transfer of arginine decarboxylase to the central nervous system on opioid analgesic tolerance
- Clustering Small Dendrimers into Nanoaggregates for Efficient DNA and siRNA Delivery with Minimal Toxicity
- Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics
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