Is Autophagy the Key Mechanism by Which the Sphingolipid Rheostat Controls the Cell Fate Decision?
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Summary
It is shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival and speculated on the diverging functions of the autophagic pathways induced by ceramide and S1P.
- Type
- article
- Published
- 2007-01-08
- Cited by
- 88
- References
- 16
- Access
- Open access
- OpenAlex
- https://openalex.org/W17035732
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8170960
Keywords
Business, Accounting
References
- Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants.
- Autophagosomes: biogenesis from scratch?
- Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy.
- Biologically active sphingolipids in cancer pathogenesis and treatment
- Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1*
- Sphingosine-1-phosphate: an enigmatic signalling lipid
- Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression
- The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway*
- Acyl-CoA-binding protein, Acb1p, is required for normal vacuole function and ceramide synthesis in Saccharomyces cerevisiae.
- Pivotal Role of the Cell Death Factor BNIP3 in Ceramide-Induced Autophagic Cell Death in Malignant Glioma Cells
- Regulation of Autophagy by Sphingosine Kinase 1 and Its Role in Cell Survival during Nutrient Starvation*
- Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.
- Inhibition of Macroautophagy Triggers Apoptosis
- Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments.
- Membrane Restructuring via Ceramide Results in Enhanced Solute Efflux*
Cited by
- Autophagy Paradox and Ceramide
- The inhibition of lung cancer cell migration by AhR-regulated autophagy
- Macroautophagy signaling and regulation.
- Multiple roles for sphingolipids in steroid hormone biosynthesis.
- Estudio del rol de la proteína VMP1 en los procesos de autofagia, muerte y sobrevida celular en la fisiopatología pancreática
- Inhibitors of Ceramidases.
- New insights into the mechanisms of macroautophagy in mammalian cells.
- Mechanical Cyclic Strain Induces Ceramide Generation in Endothelial Cells
- New insights into glycosphingolipid functions--storage, lipid rafts, and translocators.
- Sphingosine-1-phosphate (S1P) in cancer immunity and development
- Ceramide and sphingosine-1-phosphate in cancer, two faces of the sphinx
- Ceramide induced mitophagy and tumor suppression
- Sphingosine-1-phosphate as an amphipathic metabolite: its properties in aqueous and membrane environments.
- Lipids in autophagy: constituents, signaling molecules and cargo with relevance to disease.
- Autophagy as a Mechanism of Radiation Sensitization in Breast Tumor Cells
- A comprehensive glossary of autophagy-related molecules and processes (2nd edition)
- Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy*
- Ceramides as modulators of cellular and whole-body metabolism.
- Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics.
- Synthesis and biological properties of Pachastrissamine (jaspine B) and diastereoisomeric jaspines.
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