Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors.
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Summary
The results indicate that 12p gain is a functionally relevant change leading to activation of proliferation and reestablishment/maintenance of stem cell function through activation of key stem cell genes.
- Type
- article
- Published
- 2006-01-15
- Cited by
- 304
- References
- 51
- OpenAlex
- https://openalex.org/W16424014
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:15679764
Keywords
Environmental science
References
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- Application of induced pluripotent stem cell and embryonic stem cell technology to the study of male infertility
- Molecular genetics of testicular germ cell tumors.
- The Notch1-c-Myc Pathway Mediates Leukemia-Initiating Cell Activity in Mouse T-ALL Models: A Dissertation
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- Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective.
- Molekulare Pathologie der testikulären Keimzelltumoren: ein Update
- Loss of SKI Expression in Testicular Cancer Leads to an Enhanced Invasive Phenotype Through Both BMP-Dependent and BMP-Independent Pathways
- Investigating the Role of the Mammalian RAS-Association Domain Family Member 7 (RASSF7)
- The support of undifferentiated human embryonic stem cell lines by different matrices
- Der Stellenwert der Targeted-Therapie beim Hodentumor
- Genetic predisposition to testicular cancer
- BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma
- A neural origin for central nervous system germ cell tumours
- Vitamin D metabolism and effects on pluripotency genes and cell differentiation in testicular germ cell tumors in vitro and in vivo.
- Novel role for the intraflagellar transport protein CMG‐1 in regulating the transcription of cyclin‐D2, E‐cadherin and integrin‐α family genes in mouse spermatocyte‐derived cells
- Heat-shock factor 2 is a suppressor of prostate cancer invasion
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