Morphogenics as a Tool for Target Discovery and Drug Development
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Summary
Morphogenics is a platform process that employs a dominant negative MMR gene to create genetic diversity within defined cellular systems and results in a wide range of phenotypes, thus enabling the development and improvement of pharmaceutical products and the discovery of new pharmaceutical targets.
- Type
- article
- Published
- 2005-11-01
- Cited by
- 20
- References
- 19
- OpenAlex
- https://openalex.org/W16382047
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20262252
Keywords
Humanities, Philosophy
References
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- Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations
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- Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma.
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants
- Contribution of the Mismatch DNA Repair System to the Generation of Stationary-Phase-Induced Mutants of Bacillus subtilis
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- Evaluation of EMS-induced DNA damage in the single cell gel electrophoresis (Comet) assay and with flow cytometric analysis of micronuclei.
- A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype
- Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents
- Characterization of sporadic colon cancer by patterns of genomic instability.
- The Concept of Law
Cited by
- Antibody expression and production
- A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer
- Folate receptor α: A storied past and promising future in immunotherapy
- Vintafolide: a novel targeted agent for epithelial ovarian cancer.
- Farletuzumab in epithelial ovarian carcinoma
- Protein and Genome Evolution in Mammalian Cells for Biotechnology Applications
- Farletuzumab in Lung Cancer
- Role of Farletuzumab in Epithelial Ovarian Carcinoma
- Developing novel biopharmaceutical products through morphogenics
- Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha.
- Monoclonal antibodies: a morphing landscape for therapeutics
- Farletuzumab for NSCLC: exploiting a well-known metabolic pathway for a new therapeutic strategy
- Farletuzumab in the treatment of ovarian cancer
- Engineering Antibodies for Cancer Therapy
- Expression Systems for Recombinant Biopharmaceutical Production by Mammalian Cells in Culture
- Integrative Systems Biology II—Molecular Biology: Phase 2 Lead Discovery and In Silico Screening
- Improving Protein and Antibody Yields in Scalable Mammalian-Cell–Based Manufacturing
- A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer
- Anti-FR Antibody Generation and Engineering: Development of New Therapeutic Tools
- This information is current as Apoptosis in Spermatogenesis Expression of Aire and the Early Wave of Anderson and
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