In vitro photo-release of a TRPV1 agonist.
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Summary
Intracellular photolysis of a novel 'caged' Capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1.
- Type
- article
- Published
- 2006-01-01
- Cited by
- 21
- References
- 19
- OpenAlex
- https://openalex.org/W16213723
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23270693
Keywords
Business, Political science
References
- The capsaicin receptor: a heat-activated ion channel in the pain pathway
- Molecular mechanisms of nociception
- Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist
- Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region".
- Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".
- New Photoactivated Protecting Groups. 6. p-Hydroxyphenacyl: A Phototrigger for Chemical and Biochemical Probes1,2
- Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides.
- Multiple actions of anandamide on neonatal rat cultured sensory neurones
- Model compounds of caged capsaicin: design, synthesis, and photoreactivity.
- Using photolabile ligands in drug discovery and development.
- Vanilloids. 1. Analogs of capsaicin with antinociceptive and antiinflammatory activity.
- Small molecules targeting the vanilloid receptor complex as drugs for inflammatory pain
- Vanilloid (Capsaicin) receptors and mechanisms.
- A unified nomenclature for the superfamily of TRP cation channels.
- Photochemical gating of heterologous ion channels: Remote control over genetically designated populations of neurons
- Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain
- Systematic review of topical capsaicin for the treatment of chronic pain
- Current perspectives on the therapeutic utility of VR1 antagonists.
- Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?
Cited by
- Biologically active molecules with a "light switch".
- Photoactivatable, biologically-relevant phenols with sensitivity toward 2-photon excitation
- Photorelease of tyrosine from a-carboxy-6-nitroveratryl (aCNV) derivatives
- An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents
- Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.
- Optical switches and triggers for the manipulation of ion channels and pores.
- Wavelength-orthogonal photolysis of neurotransmitters in vitro.
- 7-[Bis(carboxymethyl)amino]coumarin-4-ylmethoxycarbonyl derivatives for photorelease of carboxylic acids, alcohols/phenols, thioalcohols/thiophenols, and amines.
- Caged AG10: new tools for spatially predefined mitochondrial uncoupling.
- TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.
- Caged Capsaicins: New Tools for the Examination of TRPV1 Channels in Somatosensory Neurons
- Biologisch aktive Moleküle mit “Lichtschalter”
- Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways
- Phototriggered release of tetrapeptide AAPV from coumarinyl and pyrenyl cages
- The synthesis and characterization of a series of caged neurotransmitters with two-photon sensitivity for use in vivo
- Photoactivatable Odorants for Chemosensory Research.
- Optical Assessment of Nociceptive TRP Channel Function at the Peripheral Nerve Terminal
- Optical Control of TRPV1 Channels In Vitro with Tethered Photopharmacology.
- Natural and Synthetic Alkamides
- Advanced Laser Photolysis of Caged Compounds
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