On the surviving fraction in irradiated multicellular tumour spheroids: calculation of overall radiosensitivity parameters, influence of hypoxia and volume effects
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Summary
The importance of taking into account the contribution of clonogenic hypoxic cells to radiosensitivity and with the convenience of using bounded local sensitivities to predict overall radiosensitivity parameters is concluded.
- Type
- dissertation
- Published
- 2005-04-21
- Cited by
- 12
- References
- 38
- Access
- Open access
- OpenAlex
- https://openalex.org/W15815090
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26071307
Keywords
Molecular biology, Biology
References
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- Dose, volume, and tumor-control predictions in radiotherapy.
- Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy.
- The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
- An explanatory hypothesis for early- and late-effect parameter values in the LQ model.
- An analysis of the relationship between radiosensitivity and volume effects in tumor control probability modeling.
- Inherently radioresistant cells exist in some human tumors.
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Cited by
- Linear quadratic and tumour control probability modelling in external beam radiotherapy
- Estimation of errors associated with use of linear-quadratic formalism for evaluation of biologic equivalence between single and hypofractionated radiation doses: an in vitro study.
- Three-dimensional spheroids of adipose-derived mesenchymal stem cells are potent initiators of blood vessel formation in porous polyurethane scaffolds.
- Breast Cancer Redox Heterogeneity Detectable with Chemical Exchange Satruation Transfer (CEST) MRI
- Model Predictive Static Programming with Impulse Control for Effective Radiotherapy
- Compatibility of the repairable-conditionally repairable, multi-target and linear-quadratic models in converting hypofractionated radiation doses to single doses
- Radiation resistant cancer cells enhance the survival and resistance of sensitive cells in prostate spheroids
- Comparison of hyper- and hypofractionated radiation schemes with IMRT technique in small cell lung cancer: Clinical outcomes and the introduction of extended LQ and TCP models.
- Investigating the impact of alpha/beta and LETd on relative biological effectiveness in scanned proton beams: An in vitro study based on human cell lines
- Challenges of applying multicellular tumor spheroids in preclinical phase
- Towards the virtual tumor for optimizing radiotherapy treatments of hypoxic tumors: a novel model of heterogeneous tissue vasculature and oxygenation.
- The three-dimensionality of the hiPSC-CM spheroid contributes to the variability of the field potential
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