Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.
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Summary
Current knowledge of blood flow and perfusion-related parameters, which usually go hand in hand and in turn define the cellular metabolic microenvironment of human malignancies, are summarized for predicting the acute and/or long-term response of tumors to therapy.
- Type
- article
- Published
- 1989-12-01
- Cited by
- 3,548
- References
- 207
- OpenAlex
- https://openalex.org/W1956944003
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8731135
Keywords
Blood flow, Grading (engineering), Tumor microenvironment, Perfusion, Medicine
References
- In vivo measurement of intracellular pH in human brain during different tensions of carbon dioxide in arterial blood. A 31P-NMR study.
- Chemical modification of tumour blood flow.
- In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography
- pH changes in the dermis during the course of the tuberculin skin test.
- Studies on the exchange of fluids between host and tumor. I. A method for growing "tissue-isolated" tumors in laboratory animals.
- Physiological effects of hyperthermia.
- pH studies of malignant tissues in human beings.
- Tissue blood flow and oxygenation during large vessel surgery.
- Relationship of muscular fatigue to pH and diprotonated Pi in humans: a 31P-NMR study.
- Intracapillary HbO2 saturation in tumor tissue of DS-carcinosarcoma during normoxia.
- The measurement of blood flow.
- Impact of localized microwave hyperthermia on the oxygenation status of malignant tumors.
- Blood flow, tissue oxygenation, pH distribution, and energy metabolism of murine mammary adenocarcinomas during growth.
- Skeletal and cardiac muscle oxygenation.
- Cell line and growth site as relevant parameters governing tumor tissue oxygenation.
- The glycolysis and respiration of tumors
- Prediction of Tumor Treatment Response
- Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors
- Autonomic Functions in Human Physiology
- The micro-vascular circulation of lymphangiomas: a study of Xe 133 clearance and pathology.
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- Clinical review and experimental evaluation of tumour M2-pyruvate kinase in pancreatic cancer
- Computerized histographic oxygen tension measurements of murine tumors.
- Vascular targeting therapy: potential benefit depends on tumor and host related effects.
- Magnetic resonance imaging of human melanoma xenografts in vivo: proton spin-lattice and spin-spin relaxation times versus fractional tumour water content and fraction of necrotic tumour tissue.
- Modulation of tumor cell response to chemotherapy by the organ environment
- A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU
- Evaluation of tumor blood perfusion by dynamic MRI and CT in patients undergoing thermoradiotherapy.
- The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.
- Pharmacokinetics of 5-aminolevulinic-acid-induced porphyrins in tumour-bearing mice.
- Different pH Dependency of Mitomycin C Activity in Monolayer and Three-Dimensional Cultures
- Bioluminescence imaging of metabolites in a human tumour xenograft after treatment with hyperthermia and/or the radiosensitizer pimonidazole.
- Oxygenation of tumors as evaluated by phosphorescence imaging.
- Ammonia inhibits neural cell adhesion molecule polysialylation in Chinese hamster ovary and small cell lung cancer cells
- Modulation of tumor oxygenation.
- New quinoxalinecarbonitrile 1,4-di-N-oxide derivatives as hypoxic-cytotoxic agents.
- Head and Neck Cancer: The Importance of Oxygen
- Applications of magnetic resonance in model systems: tumor biology and physiology.
- Hypoxia in a human intracerebral glioma model.
- Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix.
- Glucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathway.
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