Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage.
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Summary
The results suggest that, besides the inhibition of acid secretion, lansoprazole protection against NSAID-induced gastric damage depends on a reduction in mucosal oxidative injury, which is also responsible for an increment of sulfhydryl radical bioavailability.
- Type
- article
- Published
- 2005-07-14
- Cited by
- 77
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W15780558
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:27504661
Keywords
Lansoprazole, Piroxicam, Pharmacology, Chemistry, Myeloperoxidase
References
- Lack of Gastric Toxicity of Nitric Oxide-Releasing Indomethacin, NCX-530, in Experimental Animals
- Corticosteroid Pretreatment Prevents Small Intestinal Mucosal Lesion Induced by Acetic Acid-Perfusion Model in Rats
- The role of glutathione in the gastrointestinal tract: a review.
- Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.
- Aggravation of ischemia/reperfusion-induced gastric lesions in streptozotocin-diabetic rats.
- Achlorhydria does not protect against benign upper gastrointestinal ulcers during NSAID use
- Prevention and treatment of gastrointestinal symptoms and complications due to NSAIDs.
- Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.
- Mechanisms of protection by omeprazole against experimental gastric mucosal damage in rats.
- Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin C.
- Antioxidant properties of omeprazole
- Gastric toxicity of racemic ketoprofen and its enantiomers in rat: Oxygen radical generation and COX-expression
- A diclofenac derivative without ulcerogenic properties.
- Oxidant stress, anti-oxidants, nitric oxide and essential fatty acids in peptic ulcer disease.
- Mechanism of action of anti-inflammatory drugs.
- Lansoprazole Inhibits Oxygen‐Derived Free Radical Production from Neutrophils Activated by Helicobacter pylori
- Low levels of gastric mucosal glutathione during upper gastric bleeding associated with the use of nonsteroidal anti-inflammatory drugs
- Lansoprazole
- Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds.
- Role of endogenous sulphydryls and neutrophil infiltration in the pathogenesis of gastric mucosal injury induced by piroxicam in rats
Cited by
- Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers.
- Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy.
- Defensive Effect of Lansoprazole in Dementia of AD Type in Mice Exposed to Streptozotocin and Cholesterol Enriched Diet
- Eosinophilic esophagitis: interactions with gastroesophageal reflux disease.
- Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, anti-inflammatory effect and gastric damage in rats.
- Beneficial Effects of Camellia Oil (Camellia oleifera Abel.) on Hepatoprotective and Gastroprotective Activities.
- Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis.
- Adverse effects of incorporating ketoprofen into established rodent studies.
- Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo.
- SESAMOL ATTENUATES DICLOFENAC-INDUCED ACUTE GASTRIC MUCOSAL INJURY VIA ITS CYCLOOXYGENASE-INDEPENDENT ANTIOXIDATIVE EFFECT IN RATS
- Different Mechanisms in Formation and Prevention of Indomethacin-induced Gastric Ulcers
- Beneficial effects of Camellia Oil (Camellia oleifera Abel.) on ketoprofen-induced gastrointestinal mucosal damage through upregulation of HO-1 and VEGF.
- Plants and phytochemicals for peptic ulcer: An overview
- Clinical Efficacy of Esomeprazole in the Prevention and Healing of Gastrointestinal Toxicity Associated with NSAIDs in Elderly Patients
- Management of NSAID-Induced Gastrointestinal Toxicity
- The protective effect of nitroglycerin on gastrointestinal and renal side effects of lornoxicam in rats.
- Proton pump inhibitor therapy improves symptoms in postnasal drainage.
- Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis.
- The anti-secretory and anti-ulcer activities of esomeprazole in comparison with omeprazole in the stomach of rats and rabbits
- Sesame lignan sesamol protects against aspirin-induced gastric mucosal damage in rats
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- Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage