Artificial tertiary motifs stabilize trans-cleaving hammerhead ribozymes under conditions of submillimolar divalent ions and high temperatures.

Keywords

Transmittance, Materials science, Oxide, Metal, Thin film

References

• Molecular Cell BiologyHarvey F. Lodish — 1986
• Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMPRonald R. Breaker, Makoto Koizumi, Garrett A. Soukup — 1999
• Solvent protection of the hammerhead ribozyme in the ground state: evidence for a cation-assisted conformational change leading to catalysis.Ken J. Hampel, John M. Burke — 2003
• Activities and relative affinities of divalent metals in unmodified and phosphorothioate-substituted hammerhead ribozymes.Laura M. Hunsicker — 2000
• Structural flexibility and the thermodynamics of helix exchange constrain attenuation and allosteric activation of hammerhead ribozyme TRAPs.Vanvimon Saksmerprome, Donald H. Burke — 2003
• The global conformation of an active hammerhead RNA during the process of self-cleavage.Khaled M. A. Amiri, Paul J. Hagerman — 1996
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• The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone.James B. Murray, Attila A. Seyhan, Nils G. Walter — 1998
• Diffusely bound Mg2+ ions slightly reorient stems I and II of the hammerhead ribozyme to increase the probability of formation of the catalytic core.David Rueda, Katrin Wick, S. Elizabeth McDowell — 2003
• RNA folding and misfolding of the hammerhead ribozyme.Gurminder S. Bassi, Niels Erik Møllegaard, Alastair I.H. Murchie — 1999
• Differential binding of Mg2+, Zn2+, and Cd2+ at two sites in a hammerhead ribozyme motif, determined by 15N NMR.Gang Wang, Barbara L. Gaffney, Roger A. Jones — 2004
• Allosteric hammerhead ribozyme TRAPs.Donald H. Burke, Nicole Ozerova, Marit Nilsen‐Hamilton — 2002
• Structural analysis of metal ion ligation to nucleotides and nucleic acids using pulsed EPR spectroscopy.Charles G. Hoogstraten, Christopher V. Grant, Thomas E. Horton — 2002
• Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme.Akihiko Inoue — 2004
• Involvement of a Specific Metal Ion in the Transition of the Hammerhead Ribozyme to Its Catalytic Conformation*Alessio Peracchi, Leonid Beigelman, Edmund C. Scott — 1997
• Geometric nomenclature and classification of RNA base pairs.Neocles B. Leontis, Éric Westhof — 2001
• Simian immunodeficiency virus RNA is efficiently encapsidated by human immunodeficiency virus type 1 particlesTahir A. Rizvi, Antonito T. Panganiban — 1993

Cited by

• A general design strategy for protein-responsive riboswitches in mammalian cellsCarlos Losilla Alcalde — 2014
• Affinity purification of in vitro transcribed RNA with homogeneous ends using a 3'-ARiBo tag.Geneviève Di Tomasso, Alix Salvail-Lacoste, Jonathan Bouvette — 2014
• In vitro evolution of distinct self-cleaving ribozymes in diverse environmentsMilena Popović, Palmer Fliss, Mark A. Ditzler — 2015
• Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage ReactionAamir Mir, Chen Ji, Kyle Robinson — 2015
• Automated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcriptNawwaf Kharma, Luc Varin, Aida Abu‐Baker — 2015
• In Vitro Selection of High Temperature Zn2+-Dependent DNAzymesKevin E. Nelson, Peter J. Bruesehoff, Yi Lu — 2005
• Hammerhead ribozymes in therapeutic target discovery and validation.Lorena Tedeschi, Caterina Lande, Antonella Cecchettini — 2009
• Catalytic diversity of extended hammerhead ribozymes.Irina V. Shepotinovskaya, Olke C. Uhlenbeck — 2008
• Probing general acid catalysis in the hammerhead ribozyme.Jason M. Thomas, David M. Perrin — 2008
• Hammerhead ribozymes with cleavage site specificity for NUH and NCH display significant anti-hepatitis C viral effect in vitro and in recombinant HepG2 and CCL13 cells.Maria-Angeles Gonzalez-Carmona, Sabine Schüssler, Matthias Serwe — 2006
• The catalytic diversity of RNAsMartha J. Fedor, James R. Williamson — 2005
• Effects of the trinucleotide preceding the self-cleavage site on eggplant latent viroid hammerheads: differences in co- and post-transcriptional self-cleavage may explain the lack of trinucleotide AUC in most natural hammerheadsAlberto Carbonell, Marcos de la Peña, Ricardo Flores — 2006
• A versatile cis-blocking and trans-activation strategy for ribozyme characterizationAndrew Kennedy, Joe C. Liang, Christina D. Smolke — 2012
• Comparative single‐turnover kinetic analyses of trans‐cleaving hammerhead ribozymes with naturally derived non‐conserved sequence motifsMarc S. Weinberg, John J. Rossi — 2005
• Conformational heterogeneity and the determinants of tertiary stabilization in the hammerhead ribozyme from Dolichopoda cave cricketsManami Roychowdhury-Saha, Sugata Roychowdhury, Donald H. Burke — 2011
• Trans-cleaving hammerhead ribozymes with tertiary stabilizing motifs: in vitro and in vivo activity against a structured viroid RNAAlberto Carbonell, Ricardo Flores, Selma Gago‐Zachert — 2010
• The Different Role of High-Affinity and Low-Affinity Metal Ions in Cleavage by a Tertiary Stabilized Cis Hammerhead Ribozyme from Tobacco Ringspot VirusNatalia Kisseleva, Anastasia Khvorova, Éric Westhof — 2008
• High hydrostatic pressure approach proves RNA catalytic activity without magnesium.Agnieszka Fedoruk‐Wyszomirska, Eliza Wyszko, Małgorzata Giel-Pietraszuk — 2007
• Robust suppression of HIV replication by intracellularly expressed reverse transcriptase aptamers is independent of ribozyme processing.Margaret J. Lange, Tarun Kumar Sharma, Angela S. Whatley — 2012
• Highly active low magnesium hammerhead ribozyme.Agnieszka Fedoruk‐Wyszomirska, M. Szymański, Eliza Wyszko — 2009

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