Discovery of a novel binding trench in HIV integrase.
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Summary
Docking of the 5CITEP inhibitor to snapshots of a 2 ns HIV-1 integrase MD trajectory indicated a previously uncharacterized trench adjacent to the active site that intermittently opens, which suggests a new target for HIV- 1 therapeutics.
- Type
- article
- Published
- 2004-04-08
- Cited by
- 344
- References
- 0
- OpenAlex
- https://openalex.org/W15055986
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:984707
Keywords
Political science
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