Spontaneous mutation and parental age in humans.
Explore this paper's citation graph
Summary
A firm answer to the question of parental age and new mutation awaits identification of the molecular defect underlying some of these syndromes; a parsimonious conclusion is that mutations fall into two groups, one with a high rate of increase with age and the other with a low rate of rise with age.
- Type
- article
- Published
- 1987-08-01
- Cited by
- 259
- References
- 16
- Access
- Open access
- OpenAlex
- https://openalex.org/W14368480
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:33968140
Keywords
Incidence (geometry), Paternal age, Neurofibromatosis, Mutation rate, Apert syndrome
References
- Achondroplasia—a genetic and statistical survey
- An etiologic and nosologic overview of craniosynostosis syndromes.
- The relationship between maternal age and chromosome size in autosomal trisomy.
- Risk of dominant mutation in older fathers: evidence from osteogenesis imperfecta.
- Parental age effects on the occurrence of new mutations for the Marfan syndrome
- Note on the estimation of parental age effects
- Older paternal age and fresh gene mutation: data on additional disorders.
- The pathophysiology of neurofibromatosis: IX. Paternal age as a factor in the origin of new mutations.
- Apert's syndrome (a type of acrocephalosyndactyly)–observations on a British series of thirty‐nine cases*
- Genetic aspects of fibrodysplasia ossificans progressiva.
- Achondroplasia: an account of the condition in Northern Ireland.
- Spontaneous mutation in man.
- A subroutine package for maximum likelihood estimation (MAXLIK)
- An Introduction to Probability Theory and Its Applications
Cited by
- Wilms' tumour and parental age: a report from the National Wilms' Tumour Study.
- Crouzon Syndrome with Acanthosis Nigricans: Case Report and Mutational Analysis
- A new study challenges the current belief of a high human male:female mutation ratio.
- Ionizing radiation and genetic risks IX. Estimates of the frequencies of mendelian diseases and spontaneous mutation rates in human populations: a 1998 perspective.
- Recurrence risk of a new dominant mutation in children of unaffected parents.
- Rapid Method of Processing Sperm for Nucleic Acid Extraction in Clinical Research
- Age paternel et risques pour la descendance
- Statement on Guidance for Genetic Counseling in Advanced Paternal Age
- Independent Effects of Paternal Age and Neuregulin1 Expression in Mice in Relation to Schizophrenia
- A case report of recurrent achondroplasia in fetuses of normal parents
- Advancing our understanding of the inheritance and transmission of pectus excavatum
- Older paternal age and positive consanguinity increase the burden of β thalassemia disease
- Lenz-Majewski Syndrome Associated with Hydrocephalus and Multiple Congenital Malformations
- Male age, germline mutations and the benefits of polyandry
- The Participation of Prospective Fathers in Preconception Care
- Parental age and child growth and development: Child health check‐up data
- Cancer Development and Progression: A Non-Adaptive Process Driven by Genetic Drift
- Germ-line origins of mutation in families with hemophilia B: the sex ratio varies with the type of mutation.
- Why do we age?
- Differential effects of FGFR2 mutations on syndactyly and cleft palate in Apert syndrome.
Related papers
- Preferential mutation of the neurofibromatosis type 1 gene in paternally derived chromosomes
- Global breast cancer incidence and mortality trends by region, age-groups, and fertility patterns
- Genetics of neurofibromatosis 1 in Japan: mutation rate and paternal age effect
- Trends in incidence and mortality of esophageal cancer in China 1990−2019: A joinpoint and age-period-cohort analysis
- Trends in the incidence and survival of cancer in teenagers and young adults: regional analysis for South East England 1960-2002.
- Exclusive paternal origin of new mutations in Apert syndrome
- Sex Differences in Incidence of IDDM in Age-Group 15-29 yr: Higher risk in males in Province of Turin, Italy
- Changes in AIDS incidence trends in Spain.
- Oesophageal cancer in the Republic of Karakalpakstan.