Caspases: the executioners of apoptosis.
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Summary
The importance of caspase prodomains in the regulation of apoptosis is further highlighted by the recognition of adapter molecules, such as RAIDD [receptor-interacting protein (RIP)-associated ICH-1/CED-3-homologous protein with a death domain]/CRADD (caspase and RIP adapter with death domain), which binds to the prodomain of cspase-2 and recruits it to the signalling complex.
- Type
- review
- Published
- 1997-08-15
- Cited by
- 4,934
- References
- 156
- Access
- Open access
- OpenAlex
- https://openalex.org/W1942214720
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25236351
Keywords
Caspase, Biology, Cell biology, Inhibitor of apoptosis domain, Death domain
References
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- Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
- Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis.
- Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice.
- The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.
- Activation of caspase‐3 in axotomized rat retinal ganglion cells in vivo
- Caspase‐3 Expression by Cerebellar Granule Neurons Is Regulated by Calcium and Cyclic AMP
- Role of factors downstream of caspases in nuclear disassembly during apoptotic execution.
- Involvement of Activated Caspase‐3‐Like Proteases in N‐Methyl‐D‐Aspartate‐Induced Apoptosis in Cerebrocortical Neurons
- Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.
- Quantitative analysis of UVB‐induced apoptosis in human epidermis
- Human Malignant Glioma Therapy Using Anti-αVβ3 Integrin Agents
- Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2 alpha.
- Caspase-3 activation by β-amyloid and prion protein peptides is independent from their neurotoxic effect
- 3-m-bromoacetylamino benzoic acid ethyl ester: a new cancericidal agent that activates the apoptotic pathway through caspase-9.
- Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)--mediated cytotoxicity by selective up-regulation of TRAIL-R1.
- Drug Resistance Mechanisms to Gamma-secretase Inhibitors in Human Colon Cancer Cells
- Apoptotic Cleavage of Cytoplasmic Dynein Intermediate Chain and P150GluedStops Dynein-Dependent Membrane Motility
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