Progress in monitoring, modeling and control of bioprocesses during the last 20 years.
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Summary
The paper gives a short report on the state of the art of metabolic flux analysis and metabolic engineering and deals with advanced control of indirectly evaluated process variables by means of state estimation/observer.
- Type
- article
- Published
- 2001-02-13
- Cited by
- 276
- References
- 350
- OpenAlex
- https://openalex.org/W11165361
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22008673
Keywords
Computer science
References
- Simulation of Profit Optimization for Industrial Baker's Yeast Continuous Fermentation
- Electrospray ionization and matrix assisted laser desorption/ionization mass spectrometry: Powerful analytical tools in recombinant protein chemistry
- A comparison of neural networks and partial least squares for deconvoluting fluorescence spectra
- Real‐time monitoring of protein secretion in mammalian cell fermentation: Measurement of monoclonal antibodies using a computer‐controlled HPLC system (BioCad/RPM)
- In vivo investigations of glucose transport in Saccharomyces cerevisiae
- On-line monitoring of glucose in mammalian cell culture using a flow injection analysis (FIA) mediated biosensor.
- Protein purification by dye-ligand chromatography.
- NEURAL NETWORKS IN ESTIMATION AND CONTROL OF ANTIBODY PRODUCTION USING HYBRIDOMA CELLS IN FED-BATCH CULTURES
- CONTROL OF CONTINUOUS FERMENTATION PROCESSES BY SLIDING MODE DESIGN
- Artificial Neural Networks of Improved Reliability for Industrial Process Supervision
- IMPROVEMENTS IN THE ON-LINE PARAMETER IDENTIFICATION OF BIOPROCESSES
- Evaluation of affinity filters for protein isolation.
- Advanced Supervision of Mammalian Cell Cultures Using Hybrid Process Models
- Feedback Control of a Recombinant Fed-Batch Fermentation Using On-Line HPLC Measurements
- Pattern Recognition Methods for Fermentation Database Mining
- AN EVOLUTIONARY ALGORITHM FOR INITIAL STATE AND PARAMETER ESTIMATION IN COMPLEX BIOCHEMICAL MODELS
- Real-time Recursive Parameter Estimation for Fault Detection in Flow-Injection Analysis Systems
- Modelling and Adaptive Control of a Continuous Anaerobic Fermentation Process
- Characterisation of mycelial morphology using image analysis.
- State Estimation of a Fed-Batch Baker's Yeast Fermentation
Cited by
- Microbial Biomass Estimation
- Sequential Injection Kinetic Flow Assay for Monitoring Glycerol in a Sugar Fermentation Process by Saccharomyces cerevisiae
- Automated measurement and monitoring of bioprocesses: key elements of the M(3)C strategy.
- Towards industrial application of quasi real-time metabolic flux analysis for mammalian cell culture.
- Simultaneous approach to model building and process design using experimental design: application to chemical vapor deposition
- An advanced monitoring platform for rational design of recombinant processes.
- Bio-artificial liver support system : an evaluation of models used in demonstrating or improving metabolic and clinical efficacy
- In-Situ, Real-Time Bioreactor Monitoring by Fiber Optics Sensors
- A study of high cell density cultivation process of recombinant Helicobacter pylori multi-epitope vaccine engineering bacteria.
- Real-time monitoring and control of the specific growth rate in yeast fed-batch cultures based on Process Analytical Technology monitoring tools such as biocalorimetry and spectroscopy
- Engineered Intrinsic Bioremediation of Ammonium Perchlorate in Groundwater
- Feeding Strategies Based on Probing Control for E. coli and V. cholerae Cultivations
- Engineering challenges of BioNEMS: the integration of microfluidics, micro- and nanodevices, models and external control for systems biology.
- Optimization of Recombinant Protein Production by a Fungal Host
- Integrated microbioreactors for rapid screening and analysis of bioprocesses
- Development of automated methods using syringe based flow analysis techniques and capillary electrophoresis for biotechnological process monitoring and environmental analysis
- Model‐based optimization and pO2 control of fed‐batch Escherichia coli and Saccharomyces cerevisiae cultivation processes
- Sensors in disposable bioreactors status and trends.
- Supervision of transient anaerobic granular sludge process through quantitative image analysis and multivariate statistical techniques
- Configuration of bioreactors.
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