Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein

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Summary

Several of the MAbs generated against infected cells blocked CCR5 binding in a V3-independent manner, suggesting that they may recognize a region analogous to the conserved coreceptor binding site in gp120, a finding that has important implications for SIV neutralization assays using C CR5-negative human T-cell lines.

Type
article
Published
2000-09-01
Cited by
68
References
94
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Open access

Keywords

Computer science

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