Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies
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Summary
A HIV-1 gp120 structure in which the conserved continuous determinants are inaccessible is implied; in some cases, this inaccessibility is due to intramolecular interactions between conserved regions, and in other cases, it isDue to intermolecular interaction with other components of the glycoprotein spike.
- Type
- dissertation
- Published
- 1994-01-01
- Cited by
- 274
- References
- 69
- Access
- Open access
- OpenAlex
- https://openalex.org/W7504741
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40873204
Keywords
Ananas, Carica, Horticulture, Biology, Tropical fruit
References
- Antibodies to discontinuous or conformationally sensitive epitopes on the gp120 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humans
- Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region
- Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.
- Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees
- A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells
- Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains
- Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gp120 third variable domain
- Several antigenic determinants exposed on the gp120 moiety of HIV-1 gp160 are hidden on the mature gp120.
- Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody
- Neutralization of HIV‐1: a paradox of humoral proportions
- Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein
- Characterization of GP120 binding to CD4 and an assay that measures ability of sera to inhibit this binding.
- Strain specificity and binding affinity requirements of neutralizing monoclonal antibodies to the C4 domain of gp120 from human immunodeficiency virus type 1
- Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody
- A Hidden Region in the Third Variable Domain of HIV-1 IIIB gp120 Identified by a Monoclonal Antibody
- Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition.
- The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
- Neutralizing monoclonal antibodies to the AIDS virus.
- The HIV‐1 Surface Protein gp120 Has No Effect on Transmembrane Signal Transduction in T Cells
- Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1.
Cited by
- Anti-human immunodeficiency virus immunoconjugates.
- Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein
- Immunological and Virological Analyses of Persons Infected by Human Immunodeficiency Virus Type 1 while Participating in Trials of Recombinant gp120 Subunit Vaccines
- Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120.
- Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein
- Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding
- A Twin-Cysteine Motif in the V2 Region of gp120 Is Associated with SIV Envelope Trimer Stabilization
- Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120.
- Développement d'inhibiteurs d'entrée du virus VIH-1
- Synthetic antibodies targeting HIV-1 infectivity
- The receptor for HIV: dissection of CD4 and studies on putative accessory factors.
- HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26.
- Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors
- Characterization and Enhanced Processing of Soluble, Oligomeric gp140 Envelope Glycoproteins Derived from Human Immunodeficiency Virus Type-1 Primary Isolates
- Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells
- Modellierung der Interaktion des humanen Korezeptor CCR5 mit der V3-Loop des Glycoproteins gp120 aus dem HIV-1
- Helical epitopes determined by low‐stringency antibody screening of a combinatorial peptide library
- Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type 1 isolates elicited by immunization with oligomeric gp160
- Envelope Glycoprotein Determinants of HIV -1 Induced Membrane Fusion
- Mapping of Epitopes Exposed on Intact Human Immunodeficiency Virus Type 1 (HIV-1) Virions: a New Strategy for Studying the Immunologic Relatedness of HIV-1
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