PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis.
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Summary
The present review summarizes the current knowledge on the association between the PNPLA3 I148M variant and NAFLD, and especially its role in the development of nonalcoholic fatty liver fibrosis and explores the underlying mechanisms by speculating a pro-fibrogenic network.
- Type
- review
- Published
- 2015-01-21
- Cited by
- 46
- References
- 56
- Access
- Open access
- OpenAlex
- https://openalex.org/W9596613
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81306738
Keywords
Nonalcoholic fatty liver disease, Fatty liver, Fibrosis, Internal medicine, Metabolic syndrome
References
- Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk.
- Association ofPNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study
- Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2‐year follow‐up in normal weight and overweight children: the PANIC Study
- I148M patatin‐like phospholipase domain‐containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
- Adenosine 2A Receptor Antagonist Prevented and Reversed Liver Fibrosis in a Mouse Model of Ethanol-Exacerbated Liver Fibrosis
- Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
- Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
- From fat to inflammation.
- Hedgehog Pathway Activation Parallels Histologic Severity of Injury and Fibrosis in Human Nonalcoholic Fatty Liver Disease
- Liver: Hepatic stellate cells hold the key to liver fibrosis
- A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
- Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: non-invasive elastography-based study in chronic liver disease.
- HEDGEHOG SIGNALING IN CHOLANGIOCYTES
- Hedgehog Pathway and Pediatric Nonalcoholic Fatty Liver Disease
- Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
- The Effect of PNPLA3 on Fibrosis Progression and Development of Hepatocellular Carcinoma: A Meta-analysis
- Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease.
- The Association of Genetic Variability in PNPLA3 with Histological Severity of Non-Alcoholic Fatty Liver Disease
- PNPLA3 Variants Specifically Confer Increased Risk for Histologic Nonalcoholic Fatty Liver Disease But Not Metabolic Disease
Cited by
- Genetic Variants in the SAMM50 Gene Create Susceptibility to Nonalcoholic Fatty Liver Disease in a Chinese Han Population
- Non-alcoholic fatty liver disease
- Non-alcoholic Fatty Liver Disease
- PNPLA3 Expression Is Related to Liver Steatosis in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease
- TM6SF2 E167K Variant, a Novel Genetic Susceptibility Variant, Contributing to Nonalcoholic Fatty Liver Disease
- Non-alcoholic fatty liver disease.
- Non-alcoholic fatty liver disease
- Hepatocellular carcinoma development in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Is it going to be the "Plague" of the 21st century? A literature review focusing on pathogenesis, prevention and treatment.
- The Association between Pediatric NAFLD and Common Genetic Variants
- Non-alcoholic fatty liver disease
- PNPLA3 expression and its impact on the liver: current perspectives
- Analogy between non-alcoholic steatohepatitis (NASH) and hypertension: a stepwise patient-tailored approach for NASH treatment
- PCB-associated steatohepatitis and the role of nuclear receptors.
- Non-alcoholic fatty liver disease
- Role of the PNPLA3 polymorphism rs738409 on silymarin + vitamin E response in subjects with non-alcoholic fatty liver disease.
- EVALUATION OF MARKERS OF TARGET ORGANS PRECLINICAL DAMAGE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE COMBINED WITH METABOLIC SYNDROME DEPENDING ON THE OBESITY STAGE
- Non-Alcoholic Fatty Liver Disease.
- Non-alcoholic fatty liver disease
- Too Much of a Good Thing? An Evolutionary Theory to Explain the Role of Ceramides in NAFLD
- Gut Microbiota in Metabolic-associated Fatty Liver Disease and in Other Chronic Metabolic Diseases
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