Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome.
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Summary
NAFLD might be a more direct predictor of type 2 diabetes, cardiovascular disease, non-alcoholic steatohepatitis (NASH), and hepatocellular carcinoma than metabolic syndrome because it is associated with high liver fat content.
- Type
- review
- Published
- 2014-11-01
- Cited by
- 1,134
- References
- 120
- OpenAlex
- https://openalex.org/W2161883681
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25979699
Keywords
Metabolic syndrome, Fatty liver, Medicine, Steatohepatitis, Internal medicine
References
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- Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults
- The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population
- Oxford Handbook of Endocrinology and Diabetes
- Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5‐year prospective cohort study
- I148M patatin‐like phospholipase domain‐containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease
- Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.
- Predicting Fibrosis Worsening in Obese Patients With NASH Through Parenchymal Fibronectin, HOMA-IR, and Hypertension
- Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
- I148M variant of PNPLA3 confer increased risk for nonalcoholic fatty liver disease not only in European population, but also in Chinese population
- A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver.
- Visceral fat in relation to health: is it a major culprit or simply an innocent bystander?
- Decrease in hepatic very-low-density lipoprotein–triglyceride secretion after weight loss is inversely associated with changes in circulating leptin
- Noninvasive assessment of liver fibrosis: The clinical context and question are important
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
- A common variant in the peroxisome proliferator-activated receptor-γ coactivator-1α gene is associated with nonalcoholic fatty liver disease in obese children.
- Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent
- The Impact of Bariatric Surgery on Nonalcoholic Steatohepatitis
Cited by
- Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease
- Nonalcoholic fatty liver disease
- Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
- Patients With Lean Nonalcoholic Fatty Liver Disease Are Metabolically Abnormal and Have a Higher Risk for Mortality
- Dynapenia Rather Than Sarcopenia Is Associated with Metabolic Syndrome in Patients with Chronic Liver Diseases
- Liver Enzymes and Lifestyle
- Physical activity as a treatment of non-alcoholic fatty liver disease: A systematic review.
- Liver Steatosis and Fibrosis in OSA patients After Long-term CPAP Treatment: A Preliminary Ultrasound Study.
- Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes
- Metabolic imaging in obesity: underlying mechanisms and consequences in the whole body
- Impact of metabolic syndrome in surgical patients: should we bother?
- Review article: the efficacy of biomarkers in chronic fibroproliferative diseases – early diagnosis and prognosis, with liver fibrosis as an exemplar
- High serum microRNA-122 level is independently associated with higher overall survival rate in hepatocellular carcinoma patients
- Are there mild and serious metabolic syndromes? The need for a graded diagnosis.
- Activation of the GP130-STAT3 axis and its potential implications in nonalcoholic fatty liver disease.
- Pancreatic steatosis: Is it related to either obesity or diabetes mellitus?
- Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2.
- Non-alcoholic fatty liver disease
- Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat
- Pathogenesis and significance of hepatitis C virus steatosis: an update on survival strategy of a successful pathogen.
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