Severe spatial navigation deficit in the Morris water maze after single high dose of neonatal x-ray irradiation in the rat.
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Summary
Impairment of irradiated rats in Exp. 3 and 4 and histological examination of their brains support the conclusion that 60-70% reduction of granule cells in the dorsal hippocampus causes significant deterioration in both allocentric and egocentric orientation.
- Type
- article
- Published
- 1997-03-18
- Cited by
- 68
- References
- 25
- OpenAlex
- https://openalex.org/W9122269
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22303115
Keywords
Cell culture, Ethyl acetate, IC50, Cancer cell lines, Growth inhibition
References
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- Structure of the granular layer of the rat dentate gyrus. A light microscopic and Golgi study.
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- A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat.
- Volumetric measurements of the contractile elements of the rods and cones
- Postnatal development and synaptic connections of hilar mossy cells in the hippocampal dentate gyrus of rhesus monkeys
- Effects of lesions of the associative parietal cortex on the acquisition and use of spatial memory in egocentric and allocentric navigation tasks in the rat.
- Early effects of x-irradiation of the cerebellum in infant rats: decimation and reconstitution of the external granular layer.
- The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.
- Behavioural effects of interference with the postnatal acquisition of hippocampal granule cells.
- Spatial cognitive maps: differential role of parietal cortex and hippocampal formation.
- A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.
- Spontaneous perseverative turning in rats with radiation-induced hippocampal damage.
- Hippocampus: cognitive map or working memory?
- Exploratory activity and response to a spatial change in rats with hippocampal or posterior parietal cortical lesions.
- Contribution of egocentric spatial memory to place navigation of rats in the Morris water maze.
- Effects of discrete kainic acid-induced hippocampal lesions on spatial and contextual learning and memory in rats.
- The Hippocampus as a Cognitive Map
Cited by
- Sparing of the neural stem cell compartment during whole-brain radiation therapy: a dosimetric study using helical tomotherapy.
- Detailed Differentiation of Calbindin D-28k-Immunoreactive Cells in the Dentate Gyrus in C57BL/6 Mice at Early Postnatal Stages
- Boron Neutron Capture Therapy of Brain Tumors: Functional and Neuropathologic Effects of Blood–Brain Barrier Disruption and Intracarotid Injection of Sodium Borocaptate and Boronophenylalanine
- Comparative anatomy of the hippocampal dentate gyrus in adult and developing rodents, non-human primates and humans.
- Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells.
- Effects of Low Level Radiation exposure on Neurogenesis and Cognitive Function: Mechanisms and Prevention
- Residual granule cells can maintain susceptibility of CA3 pyramidal cells to kainate‐induced epileptiform discharges
- Applications of the Morris water maze in the study of learning and memory.
- Subnecrotic stereotactic radiosurgery controlling epilepsy produced by kainic acid injection in rats.
- Study of Molecular and Granular Layer of Dentate Gyrus of Female Rats Neonatally Treated with Estrogen
- Dentate gyrus and spatial behaviour.
- Transplantation of neurospheres after granule cell lesions in rats: cognitive improvements despite no long-term immunodetection of grafted cells.
- Anomalous neural circuit function in schizophrenia during a virtual Morris water task
- Pharmacological models of ADHD
- Animal models of attention-deficit hyperactivity disorder.
- Modulatory effect of ionizing radiation on food‐NaCl associative learning: the role of γ subunit of G protein in Caenorhabditis elegans
- Ontogeny of cocaine‐ and amphetamine‐regulated transcript (CART) peptide and calbindin immunoreactivity in granule cells of the dentate gyrus in the rat
- Effect of neonatal dentate gyrus lesion on allothetic and idiothetic navigation in rats.
- Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation.
- Long-lasting effects of neonatal ionizing radiation exposure on spatial memory and anxiety-like behavior.
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