An Antigenic Threshold for Maintaining Human Immunodeficiency Virus Type 1-specific Cytotoxic T Lymphocytes
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Summary
The findings suggest that a complex, rather than a monotonic, relationship exists between CTL levels and HIV-1 viremia, including what appears to be an antigenic threshold for the maintenance of CTL at a measurable level.
- Type
- article
- Published
- 2000-09-01
- Cited by
- 46
- References
- 21
- Access
- Open access
- OpenAlex
- https://openalex.org/W4362713
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20539497
Keywords
Cytotoxic T cell, Virology, Antigen, Human immunodeficiency virus (HIV), Immunology
References
- High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors
- Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
- Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART).
- Cytotoxic T-cell memory without antigen
- Antigen Is Required for the Activation of Effector Activities, whereas Interleukin 2 Is Required for the Maintenance of Memory in Ovalbumin-specific, CD8+ Cytotoxic T Lymphocytes
- Rapid turnover of T lymphocytes in SIV-infected rhesus macaques.
- Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen
- Lifespan of human lymphocyte subsets defined by CD45 isoforms
- Phenotypic Analysis of Antigen-Specific T Lymphocytes
- Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.
- Quantitative analysis of the human immunodeficiency virus type 1 (HIV- 1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein- Barr virus in late disease
- Longitudinal and cross-sectional analysis of cytotoxic T lymphocyte responses and their relationship to vertical human immunodeficiency virus transmission. ARIEL Project Investigators.
- The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses.
- T cell memory. Long-term persistence of virus-specific cytotoxic T cells
- Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
- Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
- Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
- Levels of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Effector and Memory Responses Decline after Suppression of Viremia with Highly Active Antiretroviral Therapy
- Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1
- Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection.
Cited by
- Immune activation and antibody responses in non‐progressing elite controller individuals infected with HIV‐1
- Generalized Necessary and Sufficient Conditions for Annihilation of HIV-1 Virions During HAART
- Interrupciones del tratamiento en la práctica clínica
- Older age and plasma viral load in HIV-1 infection
- Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy
- Determinants of HIV-specific CD8 T-cell responses in HIV-infected pediatric patients and enhancement of HIV-gag-specific responses with exogenous IL-15.
- Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.
- CD8+ T cell responses to human immunodeficiency viruses type 2 (HIV‐2) and type 1 (HIV‐1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype
- Generalized Theoretical Criteria for Annihilation of HIV-1 Virions during HAART
- Immunodominance of HIV-1 Specific CD8+ T-Cell Responses Is Related to Disease Progression Rate in Vertically Infected Adolescents
- Planned Multiple Exposures to Autologous Virus in HIV Type 1-Infected Pediatric Populations Increases HIV-Specific Immunity and Reduces HIV Viremia
- Modelling and control of HIV dynamics
- Therapeutic immunization with a human immunodeficiency virus (HIV) type 1-recombinant canarypox vaccine in chronically HIV-infected patients: The Vacciter Study (ANRS 094).
- Maintenance of HIV-Specific Central and Effector Memory CD4 and CD8 T Cells Requires Antigen Persistence
- Persistent low viral load on antiretroviral therapy is associated with T cell-mediated control of HIV replication
- Maximizing of Asymptomatic Stage of Fast Progressive HIV Infected Patient Using Embedding Method
- HIV-Specific CD8+ T Lymphocytes in Blood of Long-Term HIV-Infected Hemophilia Patients
- Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
- Therapeutic dendritic-cell vaccine for simian AIDS
- Multiobjective Optimal Control of HIV Dynamics
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