Negative Control of p53 by Sir2 Promotes Cell Survival under Stress
Explore this paper's citation graph
Summary
It is found that oncogenic Ras as well as PML cant implications regarding an important role for Sir2␣ can upregulate the levels of acetylated p53 in normal in modulating the sensitivity of cells in p53-dependent primary fibroblasts, and also induce premature senes-apoptotic response and the possible effect in cancer cence in a p53-dependent manner.
- Published
- 2001-01-01
- Cited by
- 1,951
- References
- 56
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5758078
References
- PUMA induces the rapid apoptosis of colorectal cancer cells.
- PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
- Involvement of p85 in p53-dependent apoptotic response to oxidative stress
- The function of PML in p53-dependent apoptosis
- Surfing the p53 network
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
- Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
- Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product.
- Acetylation: a regulatory modification to rival phosphorylation?
- Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes.
- Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function
- Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination
- hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
- The Sir2 protein family: A novel deacetylase for gene silencing and more.
- PML is induced by oncogenic ras and promotes premature senescence.
- Cellular differentiation.
Cited by
- Steps in Assembly of Silent Chromatin in Yeast: Sir3-Independent Binding of a Sir2/Sir4 Complex to Silencers and Role for Sir2-Dependent Deacetylation
- Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases.
- Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
- Molecular Pathogenesis of Non-Hodgkin's Lymphoma: the Role of Bcl-6
- Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.
- Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1
- Nicotinamide extends the replicative life span of primary human cells.
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.
- Deacetylation of nonhistone proteins by HDACs and the implications in cancer.
- Sirtuins — novel therapeutic targets to treat age-associated diseases
- Protective Role of SIRT1 in Diabetic Vascular Dysfunction
- Longevity nutrients resveratrol, wines and grapes
- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance.
- Sirtuins and Their Relevance to the Kidney
- After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.
- Sirtuin 1 in malignant transformation: friend or foe?
- On acetyl-CoA as a gauge of cellular metabolic state.
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- p53 N-terminal phosphorylation: a defining layer of complex regulation.
- Targeting the Oncogenic E3 Ligase Skp2 in Prostate and Breast Cancer Cells with a Novel Energy Restriction-Mimetic Agent
Related papers
No related papers recorded.