Diagnostic accuracy and predictors of alpha-synuclein accumulation in the gastrointestinal tract of Parkinson’s disease
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Summary
PD-related AS accumulation in the GI tract follows a temporally increasing but spatially static progression pattern, which suggests PD-related AS accumulation in the GI tract follows a temporally increasing but spatially static progression pattern.
- Type
- article
- Published
- 2024-08-15
- Cited by
- 10
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W4401621282
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:271881069
Keywords
Parkinson's disease, Alpha-synuclein, Gastrointestinal tract, Disease, Medicine
References
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- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss
- Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms
- The progression of pathology in longitudinally followed patients with Parkinson’s disease
- Staging of brain pathology related to sporadic Parkinson's disease.
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
- Multiple organ involvement by alpha‐synuclein pathology in Lewy body disorders
- MDS clinical diagnostic criteria for Parkinson's disease
- Pathological lesions in colonic biopsies during Parkinson’s disease
- Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: Status and recommendations The Movement Disorder Society Task Force on rating scales for Parkinson's disease
- Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology.
- Alpha‐synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker
- Pathological α‐synuclein in gastrointestinal tissues from prodromal Parkinson disease patients
- Similar α‐Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls
- Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control Subjects
- Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease
- Fundamental limit of alpha-synuclein pathology in gastrointestinal biopsy as a pathologic biomarker of Parkinson's disease: Comparison with surgical specimens.
- Enteric Pathologic Manifestations of Alpha-Synucleinopathies
- Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease
Cited by
- Plasma fibronectin is a prognostic biomarker of disability in Parkinson’s disease: a prospective, multicenter cohort study
- Spatial transcriptome analysis of myenteric plexus and intestinal epithelium of colon in patients with Parkinson’s disease
- The Small Intestinal Microbiota and the Gut–Brain Axis in Parkinson’s Disease: A Narrative Review
- Nanoencapsulated Flavonoids for Enhanced Modulation of the Microbiota-Gut-Brain Axis and Neurodegenerative Add-on Therapy
- Evaluation of an antibody panel for alpha-synuclein detection in FFPE rectal biopsies in Parkinson’s disease
- Management of Gastrointestinal Symptoms in Patients with Movement Disorders: Focusing on Parkinson's Disease
- Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson’s disease
- Neurodegeneration as Ecosystem Failure: A New Paradigm for Prevention and Treatment
- The Enteric Nervous System as a Mediator of Microbiota‐Gut‐Brain Interactions in Parkinson's Disease
- From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson’s disease
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