A regulatory loop of JAK/STAT signalling and its downstream targets represses cell fate conversion and maintains male germline stem cell niche homeostasis

Keywords

Cell biology, Biology, Stem cell, JAK-STAT signaling pathway, stat

References

• Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.Douglas A. Harrison, Richard Binari, Theresa Stines Nahreini — 1995
• Identification of in vivo DNA targets of chromatin proteins using tethered Dam methyltransferaseBas van Steensel, Steven Henikoff — 2000
• A niche maintaining germ line stem cells in the Drosophila ovary.Ting Xie, Allan C. Spradling — 2000
• Somatic support cells restrict germline stem cell self-renewal and promote differentiationAmy A. Kiger, Helen White‐Cooper, Margaret T. Fuller — 2000
• The relationship between the spleen colony-forming cell and the haemopoietic stem cell.R. Schofield — 1978
• Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye developmentYan Zhang, Jia You, Wenyan Ren — 2013
• Local BMP receptor activation at adherens junctions in the Drosophila germline stem cell niche.Marcus Michel, Isabel Raabe, Adam P. Kupinski — 2011
• Socializing with the neighbors: stem cells and their niche.Elaine Fuchs, Tudorita Tumbar, Géraldine Guasch — 2004
• Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT SignalingNatalia Tulina, Erika Matunis — 2001
• The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals.Eva Decotto, Allan C. Spradling — 2005
• The stem-cell niche as an entity of actionDavid T. Scadden — 2006
• Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testisEihachiro Kawase, Marco D. Wong, Bee Ching Ding — 2004
• Stem cells and their niche: an inseparable relationshipTing Xie, Linheng Li — 2007
• SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing discBernard A. Callus, Bernard Mathey-Prévôt — 2002
• The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes.Mary Whiteley, Philip D. Noguchi, Suzanne M. Sensabaugh — 1992
• JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functionsNatalia I. Arbouzova, Martin P. Zeidler — 2006
• chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation and stem cell self-renewal in DrosophilaMaria Sol Flaherty, Pauline Salis, Cory J. Evans — 2010
• Local signaling within stem cell niches: insights from DrosophilaLuís Pedro Resende, D. Leanne Jones — 2012
• Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway.Peter Karsten, Sabine Häder, Martin P. Zeidler — 2002
• JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell NicheMelanie Issigonis, Natalia Tulina, Margaret de Cuevas — 2009

Cited by

• Sec61β, a subunit of the Sec61 complex at the endoplasmic reticulum, coordinates with Ocnus in regulating Drosophila spermatogenesis.Qian Wang, Xin Chen, Yu‐Feng Wang — 2025
• Metabolic Regulation in the Maintenance of Drosophila Testis Stem CellsJiao Liu, Peixin Xu, Ying Liu — 2026
• ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discoveryLu Zhou, Hai Rao, Feng Rao — 2026

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