Overcoming the blood-brain barrier? - prediction of blood-brain permeability of hydrophobically modified polyethylenimine polyplexes for siRNA delivery into the brain with in vitro and in vivo models.
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Summary
PEI PXs were shown to be a suitable nanocarrier to deliver small amounts of siRNA across the BBB into the brain but more sophisticated human BBB models that better represent physiological conditions and biodistribution are required to provide highly predictive in vitro data for human CNS drug development in the future.
- Type
- article
- Published
- 2023-07-10
- Cited by
- 10
- References
- 70
- OpenAlex
- https://openalex.org/W4384120290
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:259842605
Keywords
Blood–brain barrier, Polyethylenimine, Chemistry, Biodistribution, Small interfering RNA
References
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- Screening Nylon-3 Polymers, a New Class of Cationic Amphiphiles, for siRNA Delivery
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- Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates.
- Effect of hydrophobic interactions on properties and stability of DNA-polyelectrolyte complexes.
- Triazine dendrimers as non-viral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity
- Spectrophotometric determination of polyethylenimine in the presence of an oligonucleotide for the characterization of controlled release formulations.
- Hydrophobic modifications of cationic polymers for gene delivery
- Side‐effects of a systemic injection of linear polyethylenimine–DNA complexes
- Directed self-assembly of nanoparticles.
- Effects of the gene carrier polyethyleneimines on structure and function of blood components.
- Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors
- RAFT polymerization and self-assembly of thermoresponsive poly(N-decylacrylamide-b-N,N-diethylacrylamide) block copolymers bearing a phenanthrene fluorescent α-end group
- Quantification of Plasmid DNA Copies in the Nucleus after Lipoplex and Polyplex Transfection
- A Thermodynamic Characterization of the Interaction of a Cationic Copolymer with DNA
- Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier
Cited by
- Regulating inflammation and apoptosis: A smart microgel gene delivery system for repairing degenerative nucleus pulposus.
- Tuning the Potency of Farnesol-Modified Polyethylenimine with Polyanionic Trans-Booster to Enhance DNA Delivery.
- A blood-brain barrier- and blood-brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy.
- Silver-Mediated ARGET-ATRP of Reactive Acrylates Using TPMANMe2 Ligand: A Universal Strategy for Controlled Copolymerization.
- Unlocking the secrets of NPSLE: the role of dendritic cell-secreted CCL2 in blood-brain barrier disruption
- A Prodrug Nanodevice Co-delivering Docetaxel and ROR1 siRNA for Enhanced Triple Negative Breast Cancer Therapy.
- Drug-delivery strategies using biomaterials in the field of nerve regeneration
- Amphiphilic Nanocarrier Based on Poly(ε‐Caprolactone) for Biomimetic Membrane Permeation and Controlled Lithium Delivery: An In Vitro Study
- Unraveling the role of MAG, PTEN, and NOTCH1 in axonal regeneration: a network analysis and molecular dynamics study of siRNA/drugs/nanocarriers interactions
- Exosomes miR‐369‐3p Alleviates Early Brain Injury After Subarachnoid Hemorrhage by Promoting Ferroptosis of M1 Microglia via Inhibiting iNOS/GPX4 Axis
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