The KEAP1–NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis
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Summary
It is demonstrated that NRF2 activation induces lethality that is preceded by liver abnormalities and accumulation of lysosomes, and it is found thatNRF2 activates the master regulators of l Lysosomal biogenesis, TFEB/TFE3.
- Type
- article
- Published
- 2023-05-22
- Cited by
- 43
- References
- 76
- Access
- Open access
- OpenAlex
- https://openalex.org/W4377289768
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:258843755
Keywords
TFEB, KEAP1, Transcription factor, Cell biology, Biogenesis
References
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- NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development.
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Cited by
- Protective effect of Melanogrammus aeglefinus skin oligopeptide in ultraviolet B-irradiated human keratinocytes
- Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
- Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia
- Lysosomal Dysfunction: Connecting the Dots in the Landscape of Human Diseases
- SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway.
- Cullin-3 proteins be a novel biomarkers and therapeutic targets for hyperchloremia induced by oral poisoning
- TAZ deficiency impairs the autophagy-lysosomal pathway through NRF2 dysregulation and lysosomal dysfunction
- Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production
- Research progresses on mitochondrial-targeted biomaterials for bone defect repair
- Lysosome quality control in health and neurodegenerative diseases
- Nrf2 pathways in neuroprotection: Alleviating mitochondrial dysfunction and cognitive impairment in aging.
- Cucurbitacin B ameliorates acetaminophen induced mitochondrial oxidative stress through the Nrf2 pathway
- Promising tools into oxidative stress: A review of non-rodent model organisms
- Regualtion of LAMTOR1 by Oxidative Stress in Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration Pathogenesis.
- Sulforaphane treatment mimics contractile activity-induced mitochondrial adaptations in muscle myotubes.
- Resveratrol, a food-derived polyphenol, promotes Melanosomal degradation in skin fibroblasts through coordinated activation of autophagy, lysosomal, and antioxidant pathways
- Focus on the Forgotten Organelle: Regulation of Lysosomes in Skeletal Muscle
- Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications
- Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation
- A multi-omic approach reveals iron availability influences cell fate fidelity
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