Inhibitory postsynaptic density from the lens of phase separation
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Summary
This review discusses molecular composition, organizational and regulatory features of inhibitory postsynaptic densities through the lens of the phase separation concept and in comparison with the excitatory postsynaptic densities.
- Type
- article
- Published
- 2022-05-04
- Cited by
- 7
- References
- 104
- Access
- Open access
- OpenAlex
- https://openalex.org/W4285127779
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:248649086
Keywords
Excitatory postsynaptic potential, Postsynaptic potential, Inhibitory postsynaptic potential, Postsynaptic density, Post-tetanic potentiation
References
- Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites.
- Gephyrin: a master regulator of neuronal function?
- Gephyrin: a central GABAergic synapse organizer
- Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
- The 93-kDa glycine receptor-associated protein binds to tubulin.
- The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton
- Biochemical computation for spine structural plasticity
- Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density
- Gephyrin Interacts with Dynein Light Chains 1 and 2, Components of Motor Protein Complexes
- Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo‐axonic synapses on CA1 pyramidal cells
- Clustering of Gephyrin at GABAergic but Not Glutamatergic Synapses in Cultured Rat Hippocampal Neurons
- Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation
- Activity-Dependent Regulation of Dendritic Growth and Maintenance by Glycogen Synthase Kinase 3β
- Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome
- Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.
- Cyclin-Dependent Kinase 5 Is Involved in the Phosphorylation of Gephyrin and Clustering of GABAA Receptors at Inhibitory Synapses of Hippocampal Neurons
- Organization of the core structure of the postsynaptic density
- NMDA receptor surface mobility depends on NR2A-2B subunits
- Differences in the density of GABA-A receptor alpha-2 subunits and gephyrin in brain structures of rats selected for low and high anxiety in basal and fear-stimulated conditions, in a model of contextual fear conditioning.
- Molecular structure and function of the glycine receptor chloride channel.
Cited by
- Thermodynamic modulation of gephyrin condensation by inhibitory synapse components
- The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
- Modulation of heteromeric glycine receptor function through high concentration clustering
- Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology
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