High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 Patients
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Summary
The high expression of HERV-K (HML-2) might activate the increase of interferon in COVID-19 patients, proving that HERV -K does not only play a negative role in the human body.
- Type
- article
- Published
- 2022-05-01
- Cited by
- 20
- References
- 75
- Access
- Open access
- OpenAlex
- https://openalex.org/W4229377033
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:247330999
Keywords
ISG15, Interferon, Vero cell, Gene, Interferon-stimulated gene
References
- Endogenous retroviruses in the human genome sequence
- Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages.
- Human-Specific Integrations of the HERV-K Endogenous Retrovirus Family
- Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
- Attenuation and Restoration of Severe Acute Respiratory Syndrome Coronavirus Mutant Lacking 2′-O-Methyltransferase Activity
- Human β-defensins
- Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1
- Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
- Severe Acute Respiratory Syndrome Coronavirus Evades Antiviral Signaling: Role of nsp1 and Rational Design of an Attenuated Strain
- Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
- Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays.
- IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA
- The broad-spectrum antiviral functions of IFIT and IFITM proteins
- Endogenous retroviral pathogenesis in lupus
- Type I interferons in infectious disease
- Vero cell platform in vaccine production: moving towards cell culture-based viral vaccines
- Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study.
- Gene Ontology: tool for the unification of biology
- A novel coronavirus associated with severe acute respiratory syndrome.
- Detection of Human Endogenous Retrovirus K (HERV-K) Transcripts in Human Prostate Cancer Cell Lines
Cited by
- Transcriptional and reverse transcriptional regulation of host genes by human endogenous retroviruses in cancers
- Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness
- HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia
- SARS-CoV-2 infection activates the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in the lung: a review
- Human Endogenous Retrovirus, SARS-CoV-2, and HIV Promote PAH via Inflammation and Growth Stimulation
- Expression profile of HERVs and inflammatory mediators detected in nasal mucosa as a predictive biomarker of COVID-19 severity
- The Evaluation of HERV-K np9, rec, gag Expression in Isolated Human Peripheral Blood Mononuclear Cell (PBMC) of Gastric and Colon Cancer
- SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses
- Exploring HERV-K (HML-2) Influence in Cancer and Prospects for Therapeutic Interventions
- Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children
- Unraveling the pathogenesis of viral-induced pulmonary arterial hypertension: Possible new therapeutic avenues with mesenchymal stromal cells and their derivatives.
- Human endogenous retroviruses and exogenous viral infections
- Crosstalk between human endogenous retroviruses and exogenous viruses.
- The Dual Role of cGAS-STING Signaling in COVID-19: Implications for Therapy
- Immune and vascular modulation by HERVs: the role of CXCR1 and IL18RAP in dengue severity progression
- The relationship between HERVs and exogenous viral infections: A focus on the value of HERVs in disease prediction and treatment
- Infection-Simulator, Immunostimulatory and Immunomodulatory Effects of Interferons I and III in Biological Systems: A New Era in Vaccinology and Therapeutics Possible?
- Additional file 7 of SARS-CoV-2 infection induces epigenetic changes in the LTR69 subfamily of endogenous retroviruses
- Post-acute sequelae of COVID-19: A disorder of impaired innate immune resolution - A narrative review.
- Low-Dose Interferon I and Iii-Based Nasal Sprays: A Good-Looking Covid-19 Vaccine Candidate?
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