Bone Morphogenetic Protein (BMP) signaling regulates germline stem cell self-renewal in the newly formed Drosophila testis stem cell niche
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Summary
It is found that that BMP signaling is both necessary and sufficient for maintenance of a self- renewing germline stem cell (GSC) population, and that newly formed cyst stem cells (CySCs) are a source of BMP activating ligand.
- Type
- preprint
- Published
- 2022-03-27
- Cited by
- 0
- References
- 97
- Access
- Open access
- OpenAlex
- https://openalex.org/W4220936625
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:247780771
Keywords
Biology, Cell biology, Stem cell, Bone morphogenetic protein, BMPR2
References
- Direct and long-range action of a DPP morphogen gradient.
- Regulation of BMP and activin signaling in Drosophila.
- The Drosophila cyst stem cell lineage
- Cancer Stem Cells
- Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.
- The Embryonic Development of Drosophila melanogaster
- The creation of sexual dimorphism in the Drosophila soma.
- The development of germline stem cells in Drosophila.
- The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus
- The Transgenic RNAi Project at Harvard Medical School: Resources and Validation
- BMP Signaling Controls Formation of a Primordial Germ Cell Niche within the Early Genital Ridges
- Boss/Sev signaling from germline to soma restricts germline-stem-cell-niche formation in the anterior region of Drosophila male gonads.
- Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing
- Control of Stem Cell Self-Renewal in Drosophila Spermatogenesis by JAK-STAT Signaling
- Bone Morphogenetic Protein (BMP) signaling in development and human diseases
- twist: A Myogenic Switch in Drosophila
- Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis
- New components of the Drosophila fusome suggest it plays novel roles in signaling and transport.
- Development of sexual dimorphism in the Drosophila testis
- GAL4 system in drosophila: A fly geneticist's swiss army knife
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